| Identification | Back Directory | [Name]
M 24 | [CAS]
477775-14-7 | [Synonyms]
Buloxibutid
AT2 Agonist C21
AT2 Agonist C21 (M24)
T2 Agonist Compound 21
AT2 receptor agonist C21
Carbamic acid, N-[[3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-, butyl ester | [Molecular Formula]
C23H29N3O4S2 | [MDL Number]
MFCD26936332 | [MOL File]
477775-14-7.mol | [Molecular Weight]
475.62 |
| Chemical Properties | Back Directory | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5 mg/mL (10.51 mM) | [form ]
A solid | [pka]
4.32±0.10(Predicted) | [color ]
White to yellow | [InChIKey]
XTEOJPUYZWEXFI-UHFFFAOYSA-N | [SMILES]
C(OCCCC)(=O)NS(C1SC(CC(C)C)=CC=1C1=CC=C(CN2C=NC=C2)C=C1)(=O)=O |
| Hazard Information | Back Directory | [Uses]
Buloxibutid (AT2 receptor agonist C21) is a agentlike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 μM for the AT2 receptor and AT1 receptor, respectively[1]. | [in vivo]
Buloxibutid, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat, induces outgrowth of neurite cells, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats, and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats[1]. | [IC 50]
AT2 Receptor: 0.4 nM (Ki); AT1 Receptor: >10 μM (Ki) | [References]
[1] Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004 Nov 18;47(24):5995-6008. DOI:10.1021/jm049715t
[2] Schwengel K, Namsolleck P, Lucht K, et al. Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice. J Mol Med (Berl). 2016;94(8):957-966. DOI:10.1007/s00109-016-1406-3
[3] Fatima N, Patel S, Hussain T. Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10. Front Pharmacol. 2021;12:600163. DOI:10.3389/fphar.2021.600163 |
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