| Identification | Back Directory | [Name]
CD80-IN-3 | [CAS]
486449-65-4 | [Synonyms]
CD80-IN-3
4-(6-Fluoro-3-oxo-3,5-dihydro-2H-pyrazolo[4,3-c]quinolin-2-yl)benzoic acid
Benzoic acid, 4-(6-fluoro-3,5-dihydro-3-oxo-2H-pyrazolo[4,3-c]quinolin-2-yl)-
inhibit,CD28,CD80IN3,cell,autoimmune,CD-80-IN-3,arthritis,CD80,inflammatory,CD80 IN 3,Inhibitor,rheumatoid | [Molecular Formula]
C17H10FN3O3 | [MDL Number]
MFCD32701897 | [MOL File]
486449-65-4.mol | [Molecular Weight]
323.28 |
| Chemical Properties | Back Directory | [Boiling point ]
505.6±60.0 °C(Predicted) | [density ]
1.56±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.18±0.10(Predicted) | [color ]
Light brown to yellow |
| Hazard Information | Back Directory | [Uses]
CD80-IN-3, a potent CD80 inhibitor, inhibits CD80/CD28 interaction with an EC50 of 630 nM and a Kd of 125 nM. | [References]
[1] Huxley P, et al. High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy. Chem Biol. 2004 Dec;11(12):1651-8. DOI:10.1016/j.chembiol.2004.09.011 |
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