| Identification | Back Directory | [Name]
GGTI-2418 | [CAS]
501010-06-6 | [Synonyms]
GGTI-2418
GGTI2418;PTX 100
GGTI 2418
(GGTI2418
(S)-3-benzyl-1-((4-methyl-1-trityl-1H-imidazol-5-yl)methyl)piperazin-2-one
L-Leucine, N-[[(2S)-4-[(4-methyl-1H-imidazol-5-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-
L-Leucine, N-[[(2S)-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-
(S)-2-((S)-2-Benzyl-4-((5-methyl-1H-imidazol-4-yl)methyl)-3-oxopiperazine-1-carboxamido)-4-methylpentanoic acid | [Molecular Formula]
C23H31N5O4 | [MDL Number]
MFCD25976818 | [MOL File]
501010-06-6.mol | [Molecular Weight]
441.52 |
| Chemical Properties | Back Directory | [Boiling point ]
807.5±65.0 °C(Predicted) | [density ]
1.270±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO:125.0(Max Conc. mg/mL);283.11(Max Conc. mM) | [form ]
A crystalline solid | [pka]
4.30±0.21(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
GGTI 2418 is a geranylgeranyltransferase I inhibitor. | [in vivo]
GGTI-2418 (100 mg/kg daily or 200 mg/kg every third day; 15 days) significantly inhibits the growth of breast tumor xenografts in nude mice with MDA-MB-231 xenografts[1].
GGTI-2418 (100 mg/kg daily; 5 days) induces regression of ErbB2-driven mammary tumors in ErbB2 transgenic mice[1].
GGTI-2418 inhibits the geranylgeranylation of Rap1 and causes a dramatic decrease in S473 phosphorylation of Akt. GGTI-2418 also upregulates p27 levels in vivo[1]. | Animal Model: | Nude mice implanted with MDA-MB-231 breast cancer tumors[1] | | Dosage: | 100 mg/kg daily or 200 mg/kg every third day | | Administration: | Injected intraperitoneally; 15 days | | Result: | Inhibited the growth of breast tumor xenografts. |
| Animal Model: | ErbB2 transgenic mice[1] | | Dosage: | 100 mg/kg/day | | Administration: | Subcutaneously; 5 days | | Result: | Halted tumor growth and induced massive tumor regression. Tumor decreased by 76% following GGTI-2418 treatment. |
| [storage]
Store at -20°C |
|
| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0.htm |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
|