| Identification | Back Directory | [Name]
14,15-EE-8(Z)-E | [CAS]
519038-93-8 | [Synonyms]
14,15-EE-8(Z)-E
FFYIZOYJCCKMDJ-FHLMBLHRSA-N
14,15-EE-8(Z)-E Exclusive
14,15-Epoxy-8(Z)-Eicosaenoic Acid
13[(2(R),3S)-3-pentyloxiranyl]-8(Z)-tridecenoic acid
8-Tridecenoic acid, 13-[(2R,3S)-3-pentyl-2-oxiranyl]-, (8Z)-rel- | [Molecular Formula]
C20H36O3 | [MDL Number]
MFCD18427970 | [MOL File]
519038-93-8.mol | [Molecular Weight]
324.5 |
| Hazard Information | Back Directory | [Description]
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET. | [Uses]
14,15-EE-8(Z)-E (14,15-Epoxyeicosa-8(Z)-enoic acid) has potent vasodilator agonist activity in bovine coronary arteries. 14,15-EE-8(Z)-E is a 14,15-EET (HY-113489) analog. EETs represent important mediators of coronary vascular tone[1]. | [References]
[1] Falck JR, et al. Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation. Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H337-49. DOI:10.1152/ajpheart.00831.2001 |
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