| Identification | More | [Name]
6-Methoxyquinoline | [CAS]
5263-87-6 | [Synonyms]
6-METHOXYQUINOLINE
methyl 6-quinolyl ether
P-QUINANISOLE
QUINOLINE, 6-METHOXY-
TIMTEC-BB SBB008352
6-methoxy-quinolin
Methoxyquinoline,95%
6-Methoxyquinoline, 98+%
6-quinanisole | [EINECS(EC#)]
226-077-2 | [Molecular Formula]
C10H9NO | [MDL Number]
MFCD00006800 | [Molecular Weight]
159.18 | [MOL File]
5263-87-6.mol |
| Chemical Properties | Back Directory | [Appearance]
colorless to light yellow liquid | [Melting point ]
18-20 °C (lit.) | [Boiling point ]
140-146 °C/15 mmHg (lit.) | [density ]
1.15 g/mL at 20 °C(lit.)
| [FEMA ]
4640 | 6-METHOXYQUINOLINE | [refractive index ]
n20/D 1.625(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
soluble in Alcohol | [form ]
Granular Powder | [pka]
5.03(at 20℃) | [color ]
White to cream | [Odor]
heavy sweet | [Water Solubility ]
insoluble | [Sensitive ]
Light Sensitive | [Usage]
A useful sythetic intermediate | [Detection Methods]
HPLC | [JECFA Number]
2157 | [BRN ]
115244 | [InChI]
1S/C10H9NO/c1-12-9-4-5-10-8(7-9)3-2-6-11-10/h2-7H,1H3 | [InChIKey]
HFDLDPJYCIEXJP-UHFFFAOYSA-N | [SMILES]
COc1ccc2ncccc2c1 | [LogP]
2.17 | [CAS DataBase Reference]
5263-87-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Quinoline, 6-methoxy-(5263-87-6) | [Storage Precautions]
Light sensitive | [EPA Substance Registry System]
5263-87-6(EPA Substance) |
| Questions And Answer | Back Directory | [Preparation]
Currently, the Skraup synthesis method is mostly used for the synthesis of 6-methoxyquinoline. The Skraup synthesis method involves reacting aromatic amines, glycerol or α,β-unsaturated aldehydes or ketones, sulfuric acid and nitrobenzene (corresponding to the aromatic amine used), arsenic pentoxide or ferric chloride and other oxidizing agents together to generate quinoline and its derivatives. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319 | [Precautionary statements ]
P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [F ]
8 | [TSCA ]
Yes | [HS Code ]
29334990 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
colorless to light yellow liquid | [Uses]
6-Methoxyquinoline is used as a precursor in the synthesis of:
- Fluorescent zinc and chlorine sensors.
- 5-Amino-2-aroylquinolines as potent tubulin polymerization inhibitors.
- 3-Fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase.
- Cobalt-based ternary metal-organic complex as single?ion magnets.
| [Uses]
6-Methoxyquinoline is a useful sythetic intermediate
| [Definition]
ChEBI: An aromatic ether that is quinoline substituted at position 6 by a methoxy group. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 68, p. 1584, 1946 DOI: 10.1021/ja01212a062 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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