ChemicalBook--->CAS DataBase List--->1435-55-8

1435-55-8

1435-55-8 Structure

1435-55-8 Structure
IdentificationMore
[Name]

HYDROQUINIDINE
[CAS]

1435-55-8
[Synonyms]

DIHYDROQUINIDINE
HYDROQUINIDINE
(9s)-10,11-dihydro-6’-methoxycinchonan-9-ol
(9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol
10,11-Dihydroquinidine
11-dihydro-6’-methoxy-1(9s)-cinchonan-9-o
6'-Methoxy-10,11-dihydrocinchonan-9-ol
Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)-
Hydroconchinine
Hydroconquinine
hydroquinidine anhydrous
Hydroxyquinidine
2-Hydroquinidine
Hydroquinidine (base and/or unspecified salts)
(1β,4β,7R,αS)-α-(6-Methoxy-4-quinolyl)-5β-ethyl-1-azabicyclo[2.2.2]octane-7-methanol
Hydroqninidine
(5-Ethyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol
(8a,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol
[EINECS(EC#)]

215-862-5
[Molecular Formula]

C20H26N2O2
[MDL Number]

MFCD00135599
[Molecular Weight]

326.43
[MOL File]

1435-55-8.mol
Chemical PropertiesBack Directory
[Melting point ]

169-170 °C(lit.)
[alpha ]

226 º (C=2 IN ETOH)
[Boiling point ]

464.47°C (rough estimate)
[density ]

1.1117 (rough estimate)
[refractive index ]

1.6800 (estimate)
[storage temp. ]

Keep in dark place,Sealed in dry,Room Temperature
[solubility ]

chloroform: 0.1 g/mL, clear
[form ]

A crystalline solid
[pka]

12.80±0.20(Predicted)
[color ]

White to off-white
[Optical Rotation]

[α]25/D +226°, c = 2 in ethanol
[Merck ]

13,4831
[BRN ]

91441
[InChIKey]

LJOQGZACKSYWCH-LHFMAAMQSA-N
[CAS DataBase Reference]

1435-55-8(CAS DataBase Reference)
[NIST Chemistry Reference]

Hydroquinidine(1435-55-8)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312-P501
[Hazard Codes ]

Xn
[Risk Statements ]

R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
[Safety Statements ]

S36/37:Wear suitable protective clothing and gloves .
S36:Wear suitable protective clothing .
[RIDADR ]

1544
[WGK Germany ]

3
[RTECS ]

MX3016000
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[HS Code ]

29339900
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Hydroquinine
[Preparation Products]

Hydroquinine (anthraquinone-1 4-diyl)-->Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (8α,9S)--->Hydroquinidine (anthraquinone-1,4-diyl) diether-->(DHQD)2PYR-->(DHQD)2PHAL-->9-AMino(9-deoxy)epi-diquinidine trihydrochloride-->Dihydroquinidine Acetate
Hazard InformationBack Directory
[Chemical Properties]

Solid
[Uses]

antiarrhythmic, antimalarial
[Purification Methods]

It is slightly soluble in Et2O and H2O but readily soluble in hot EtOH. [Heidelberger & Jacobs J Am Chem Soc 41 826 1919, King J Chem Soc 523 1946.] The hydrochloride has m 273-274o, [] 26D +184o (c 1.3, MeOH) and is very soluble in MeOH and CHCl3, but less soluble in H2O, EtOH and still less soluble in dry Me2CO. [Kyker & Lewis J Biol Chem 157 707 1945, Emde Helv Chim Acta 15 557 1932, Beilstein 23/13 V 340.]
Spectrum DetailBack Directory
[Spectrum Detail]

HYDROQUINIDINE(1435-55-8)1HNMR
HYDROQUINIDINE(1435-55-8)Raman
HYDROQUINIDINE(1435-55-8)IR
HYDROQUINIDINE(1435-55-8)FT-IR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

1435-55-8(sigmaaldrich)
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