| Identification | Back Directory | [Name]
1-Boc-4-methylpiperazine | [CAS]
53788-49-1 | [Synonyms]
1-BOC-4-METHYLPIPERAZINE
N-Boc-N-methylpiperazine
N-Boc-N-Methylpiperazine-d3
4-Methylpiperazine, N1-BOC protected
1-Methyl-4-(tert-butoxycarbonyl)piperazine
tert-butyl 4-methylpiperazine-1-carboxylate
4-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
4-Methylpiperazine-1-carboxylic Acid tert-Butyl Ester-d3
4-Methyl-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
4-Methyl-1-piperazinecarboxylic Acid 1,1-DiMethylethyl Ester-d3
tert-Butyl 4-methylpiperazine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-methylpiperazine | [Molecular Formula]
C10H20N2O2 | [MDL Number]
MFCD03840525 | [MOL File]
53788-49-1.mol | [Molecular Weight]
200.28 |
| Chemical Properties | Back Directory | [Appearance]
Colorless Oil | [Boiling point ]
254.8±33.0 °C(Predicted) | [density ]
1.023±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform, Dichloromethane, Ethyl Acetate, Methanol | [form ]
Oil | [pka]
6.90±0.10(Predicted) | [color ]
Colorless |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless Oil | [Uses]
Used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors. | [Synthesis]
Di-tert-butyl dicarbonate (3.48 mL, 15.0 mmol) was slowly added to a solution of N-methylpiperazine (1.00 g, 10.0 mmol) in tetrahydrofuran (10 mL) under ice bath cooling conditions. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solution was concentrated and the product was purified by silica gel column chromatography. The grades containing 1-boc-4-methylpiperazine were collected, concentrated and dried under reduced pressure to afford the target compound 1-boc-4-methylpiperazine (2.15 g, quantitative yield). The structure of the product was confirmed by 1H-NMR (CDCl3), δ: 3.44 (4H, t, J = 5.0 Hz), 2.34 (4H, t, J = 5.0 Hz), 2.29 (3H, s), 1.46 (9H, s). | [References]
[1] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[2] Patent: EP2703406, 2014, A1. Location in patent: Paragraph 0392
[3] Asian Journal of Chemistry, 2017, vol. 29, # 6, p. 1313 - 1316
[4] Tetrahedron Letters, 2009, vol. 50, # 46, p. 6244 - 6246
[5] Journal of Organic Chemistry, 2006, vol. 71, # 21, p. 8283 - 8286 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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