| Identification | More | [Name]
Pyrimidinetetramine sulfate | [CAS]
5392-28-9 | [Synonyms]
2,4,5,6-TETRAAMINIOPYRIMIDINE SULFATE
2,4,5,6-TETRAAMINO-PYRIMIDINE SULFATE SALT
2,4,5,6-TETRAAMINOPYRIMIDINE SULPHATE
PYRIMIDINE-2,4,5,6-TETRAMINE SULPHATE
pyrimidinetetrayltetraamine sulphate
2,4,5,6-Pyrimidinetetraamine sulfate salt
2,4,5,6-Tetramino Pyridine Sulfate
pyrimidinetetramine sulphate
TETRAAMINOPYRIMIDINE SULFATE
2,4,5,6-Tetraamino pyrimidine-H2SO4
2,4,5,6-TETRAAMINOPYRIMIDINE SULFATE, 97 %
2,4,5,6-Tetraminopyrimidinesulphate
Pyrimidinetetramine, sulfate (1:1)
2,4,5,6-tetraaminopyrimidine sulfate (intermediate of methotrexate)
Pyrimidinetetrayltetraamine sulfate.
2,4,5,6-TETRAAMINOPYRIMIDINESULFATESESQUIHYDRATE
2,4,5,6-TETRAAMINOPYRIMIDINESULFATEHEMIHYDRATE
TETRA-AMINOPYRIMIDINESULPHATE
2,4,5,6-tetroaminopyrimidine sulfate
2,4,5,6-TETRAMINOPYRIMIDINE SULFATE 99+% | [EINECS(EC#)]
226-393-0 | [Molecular Formula]
C4H10N6O4S | [MDL Number]
MFCD00012786 | [Molecular Weight]
238.23 | [MOL File]
5392-28-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow crystal powder | [Melting point ]
>300 °C(lit.)
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly, Heated), Water (Very Slightly, Heated) | [form ]
Crystalline Powder | [color ]
Ochre to brown | [Water Solubility ]
slightly soluble | [BRN ]
3785189 | [Cosmetics Ingredients Functions]
HAIR DYEING | [InChI]
InChI=1S/C4H8N6.H2O4S/c5-1-2(6)9-4(8)10-3(1)7;1-5(2,3)4/h5H2,(H6,6,7,8,9,10);(H2,1,2,3,4) | [InChIKey]
MQEFDQWUCTUJCP-UHFFFAOYSA-N | [SMILES]
NC1=C(N=C(N)N=C1N)N.S(O)(O)(=O)=O | [CAS DataBase Reference]
5392-28-9(CAS DataBase Reference) | [EPA Substance Registry System]
5392-28-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
UV9738000 | [TSCA ]
Yes | [HS Code ]
29335990 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
2,4,6-Triaminopyrimidine-->Ethyl cyanoacetate-->Urea-->4-Pyrimidinol, 2,6-diamino- (9CI)-->2,4,5-TRIAMINO-6-PYRIMIDINOL DIHYDROCHLORIDE | [Preparation Products]
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide-->N10-(TRIFLUOROACETYL)PTEROIC ACID-->Pteridine (6CI,7CI,8CI,9CI)-->2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE-->2,4,5,6-TETRAAMINOPYRIMIDINE-->Methotrexate-->Fludarabine |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow crystal powder | [Uses]
Intermediate in the production of Methotrexate | [Synthesis]
Pyrimidinetetramine sulfate is synthesized from malononitrile and guanidine nitrate through a three-step reaction involving cyclization, nitrosation, and reduction. This process uses zinc powder instead of the expensive reducing agent Raney nickel, resulting in lower costs, simpler operation, and greater safety and environmental friendliness. | [Purification Methods]
Purify the salt by recrystallisation from H2O, 2N H2SO4 (20 parts, 67% recovery) or 0.1N H2SO4 (40 parts, 62% recovery), and dried in air. [UV: Konrad & Pfleiderer Chem Ber 103 722 1970, Malletta et al. J Am Chem Soc 69 1814 1947, Cavalieri et al. J Am Chem Soc 70 3875 1948, Beilstein 25 H 423, 25 III/IV 3106.] | [References]
[1] SAUMYA SHUKLA. Toxic potential assessment of hair dye developer 2,4,5,6-tetraaminopyrimidine sulfate exposed under ambient UVB radiation.[J]. Toxicology and Industrial Health, 2024: 1-8. DOI:10.1177/07482337231209352.
[2] https://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_152.pdf |
| Well-known Reagent Company Product Information | Back Directory | [Acros Organics]
2,4,5,6-Tetraaminopyrimidine sulfate, 98%(5392-28-9) | [Alfa Aesar]
2,4,5,6-Tetraaminopyrimidine sulfate, 97%(5392-28-9) | [Sigma Aldrich]
5392-28-9(sigmaaldrich) | [TCI AMERICA]
2,4,5,6-Tetraaminopyrimidine Sulfate,>98.0%(T)(5392-28-9) |
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