| Identification | Back Directory | [Name]
4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)- | [CAS]
546105-61-7 | [Synonyms]
Carbonic anhydrase inhibitor 7
4-Quinolinecarboxamide, N-[4-(aminosulfonyl)phenyl]-2-(1,3-benzodioxol-5-yl)- | [Molecular Formula]
C23H17N3O5S | [MOL File]
546105-61-7.mol | [Molecular Weight]
447.46 |
| Hazard Information | Back Directory | [Uses]
Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with Kis of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively[1]. | [References]
[1] Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247. DOI:10.1016/j.ejmech.2022.114247 |
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