| Identification | More | [Name]
1-Boc-(4-benzyl)piperazine | [CAS]
57260-70-5 | [Synonyms]
1-BENZYL-4-BOC-PIPERAZINE
4-BENZYL-1-BOC-PIPERAZINE
4-BENZYL-1-T-BUTOXYCARBONYLPIPERAZINE
4-BENZYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
BUTTPARK 146\06-23
TERT-BUTYL 4-BENZYL-1-PIPERAZINECARBOXYLATE
TERT-BUTYL 4-BENZYLPIPERAZINE-1-CARBOXYLATE
1-Benzyl-4-(tert-butoxycarbonyl)piperazine~tert-Butyl 4-benzyl-1-piperazinecarboxylate
1-N-Boc-4-benzylpiperazine
1-Benzyl-4-(tert-butoxycarbonyl)piperazine
1-Boc-4-Benzylpiperazine | [Molecular Formula]
C16H24N2O2 | [MDL Number]
MFCD00075603 | [Molecular Weight]
276.37 | [MOL File]
57260-70-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
2933599590 |
| Hazard Information | Back Directory | [General Description]
1-Boc-(4-benzyl)piperazine is an heterocyclic building block. | [Synthesis]
To a stirred solution of N-BOC-piperazine (6.0 g, 33.0 mmol, 1.0 eq.) in acetonitrile (60 mL), the reaction mixture was cooled to 0°C. Subsequently, triethylamine (22 mL, 161 mmol, 5.0 eq.) and benzyl bromide (6.0 mL, 35.0 mmol, 1.1 eq.) were added slowly and dropwise. The reaction mixture was stirred continuously for about 6 hours at room temperature. After completion of the reaction, the mixture was diluted with water and extracted with dichloromethane (CH2Cl2). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 1-benzyl-4-Boc-piperazine (6.5 g, 76.0% yield) as a white solid. | [References]
[1] Synthetic Communications, 2009, vol. 39, # 13, p. 2297 - 2303
[2] Patent: WO2017/17630, 2017, A1. Location in patent: Page/Page column 34-35
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 4, p. 1830 - 1842
[4] Patent: WO2017/58716, 2017, A1. Location in patent: Paragraph 00268
[5] Journal of Heterocyclic Chemistry, 2010, vol. 47, # 1, p. 54 - 62 |
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