| Identification | Back Directory | [Name]
LICOCHALCONEB | [CAS]
58749-23-8 | [Synonyms]
LICOCHALCONEB
Licoagrochalcone B
3,4,4'-Trihydroxy-2-Methoxychalcone
3,4,4'-Trihydroxy-2-methoxy-trans-chalcone
(E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
2-Propen-1-one,3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)- | [Molecular Formula]
C16H14O5 | [MDL Number]
MFCD20527294 | [MOL File]
58749-23-8.mol | [Molecular Weight]
286.28 |
| Chemical Properties | Back Directory | [Melting point ]
196-197℃ | [Boiling point ]
550.5±50.0 °C(Predicted) | [density ]
1.369±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
7.80±0.15(Predicted) | [color ]
White | [biological source]
plant | [Water Solubility ]
water: slightly soluble |
| Hazard Information | Back Directory | [Chemical Properties]
LICOCHALCONEB is a yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents,and it is derived from licorice rhizomes. | [Uses]
LICOCHALCONEB has anti-tumor, anti-inflammatory, and antioxidant effects.It can be used for content determination, identification, pharmacological experiments, etc. | [Definition]
ChEBI: Licochalcone B is a member of chalcones. | [Biological Activity]
LICOCHALCONEB is extracted from Glycyrrhizainflate root. LICOCHALCONEB inhibits the self-aggregation of amyloid β (Aβ420) (IC50=2.16 μM) and disintegrates pre-formed Aβ42 fibrils, reducing metal-induced Aβ42 aggregation by chelating metal ions. |
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