| Identification | More | [Name]
Ethyl cyanoformate | [CAS]
623-49-4 | [Synonyms]
CYANOFORMIC ACID ETHYL ESTER
ETHYL CYANOFORMATE
[(Cyanocarbonyl)oxy]ethane
C2H5OC(O)CN
carbocyanidicacidethylester
Carbonocyanidic acid, ethyl ester
carbonocyanidicacid,ethylester
Formic acid, cyano-, ethyl ester
Nitriloaceticacidethylester
Ethylcyanoformate,99%
Ethoxycarbonyl Cyanide
NSC 65347 | [EINECS(EC#)]
210-797-9 | [Molecular Formula]
C4H5NO2 | [MDL Number]
MFCD00001836 | [Molecular Weight]
99.09 | [MOL File]
623-49-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear Colourless Liquid | [Boiling point ]
115-116 °C (lit.) | [density ]
1.003 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.381(lit.)
| [Fp ]
76 °F
| [storage temp. ]
Flammables area | [solubility ]
Miscible with chloroform and methanol. | [form ]
Liquid | [color ]
Clear colorless | [Specific Gravity]
1.01 | [Sensitive ]
Moisture Sensitive | [BRN ]
635955 | [Exposure limits]
NIOSH: IDLH 25 mg/m3 | [InChI]
1S/C4H5NO2/c1-2-7-4(6)3-5/h2H2,1H3 | [InChIKey]
MSMGXWFHBSCQFB-UHFFFAOYSA-N | [SMILES]
CCOC(=O)C#N | [CAS DataBase Reference]
623-49-4(CAS DataBase Reference) | [NIST Chemistry Reference]
NCCOOC2H5(623-49-4) | [EPA Substance Registry System]
623-49-4(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS05 | [Signal word ]
Danger | [Hazard statements ]
H226-H314 | [Precautionary statements ]
P210-P280-P303+P361+P353-P305+P351+P338+P310 | [Hazard Codes ]
T,F | [Risk Statements ]
R10:Flammable.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S24/25:Avoid contact with skin and eyes .
S16:Keep away from sources of ignition-No smoking .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 3275 6.1/PG 2
| [WGK Germany ]
3
| [F ]
10-19-21 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29269090 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
Clear Colourless Liquid | [Uses]
Ethyl cyanoformate is used as reagent in the preparation of N-substituted amindinoformic acid and ethyl-4-quinazoline -2-carboxylate. | [Application]
Ethyl cyanoformate can be used as a cyanide source for the cyanation of:
Activated olefins in the presence of a titanium catalyst.
Carbonyl compounds catalyzed by 4-dimethylaminopyridine (DMAP) to yield corresponding cyanohydrin carbonates under metal-free and solvent-free conditions.
Aldehydes and 2,2,2-trifluoroacetophenone catalyzed by N-heterocyclic carbene (NHC) to yield corresponding cyanohydrins ethyl carbonates.
Ethyl cyanoformate is a general cyanating agent. It can be used in the nucleophilic addition of cyanide to carbonyl compounds, oxidative cyanation of tertiary amines and in the synthesis of β-cyano-substituted acrylates from alkynes. | [Synthesis]
Ethyl cyanoformate was synthesized in the following steps:
S1, clean the reactor, add 100KG S-1500 aromatic solvent in the reactor;
S2, add 695KG ethyl chloroformate and 175KG hydrocyanic acid in the drip kettle;
S3, add 30KG tr | [Purification Methods]
Dissolve the cyanoformate in Et2O, dry it over Na2SO4, filter, evaporate and distil it [Malachowsky et al. Chem Ber 70 1016 1937, Adickes et al. J Prakt Chem [2] 133 313 1932, Grundmann et al. Justus Liebigs Ann Chem 577 77 1952]. [Beilstein 2 IV 1862.] | [Precautions]
Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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