| Identification | More | [Name]
Formylhydrazine | [CAS]
624-84-0 | [Synonyms]
FORMIC ACID HYDRAZIDE
FORMIC HYDRAZIDE
FORMOHYDRAZIDE
FORMYLHYDRAZINE
Carbazaldehyde
Formal hydrazine
formalhydrazine
Formhydrazid
Formhydrazide
Formylhydrazide
formyl-hydrazin
Hydrazine, formyl-
hydrazinecarboxaldehyde
Hydrazinecarboxaldehyde-
N-Formylhydrazine
Formicacidhydrazide,98% | [EINECS(EC#)]
210-867-9 | [Molecular Formula]
CH4N2O | [MDL Number]
MFCD00007589 | [Molecular Weight]
60.06 | [MOL File]
624-84-0.mol |
| Chemical Properties | Back Directory | [Appearance]
white shiny crystalline flakes | [Melting point ]
52-57 °C (lit.) | [Boiling point ]
90°C/0.7mmHg(lit.) | [density ]
1.094±0.06 g/cm3(Predicted) | [refractive index ]
1.4840 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
water: soluble2.5%, clear, colorless | [form ]
Shiny Crystalline Flakes | [pka]
13.65±0.20(Predicted) | [color ]
White | [Water Solubility ]
Soluble | [Sensitive ]
Hygroscopic | [BRN ]
635759 | [InChI]
1S/CH4N2O/c2-3-1-4/h1H,2H2,(H,3,4) | [InChIKey]
XZBIXDPGRMLSTC-UHFFFAOYSA-N | [SMILES]
[H]C(=O)NN | [CAS DataBase Reference]
624-84-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Formic acid hydrazide(624-84-0) | [EPA Substance Registry System]
624-84-0(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
LQ8615000
| [F ]
3-8-10 | [TSCA ]
Yes | [HS Code ]
29280000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Ethanol-->Ethyl formate-->Water-->Hydrazine hydrate-->Methanol | [Preparation Products]
Thiocarbohydrazide-->4-Amino-4H-1,2,4-triazole-->(S)-[2-(Benzyloxy)propylidene]hydrazinecarboxaldehyde-->4-(4H-1,2,4-Triazol-4-yl)benzoic acid-->5-(2-Chlorophenyl)-1H-tetrazole-->3H-1,3,4-oxadiazole-2-thione-->4-(3-Chlorophenyl)-4H-1,2,4-triazole-3-thiol-->1-Methylethylidene hydrazine carboxaldehyde-->1H-1,2,4-Triazole, 5-(diethoxymethyl)--->1,2,4-Triazolo[3,4-b]benzothiazole |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE SHINY CRYSTALLINE FLAKES | [Uses]
Formic acid hydrazide is used as a precursor in the preparation of 1,2,4-triazole derivatives. It is also used in the synthesis of 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]-pyrrolo[3,4-c]carbazole-5,7(6H)-dione, which is an anticancer agent. | [Synthesis]
a) Preparation of Formylhydrazine: Mix ethyl formate (200 g) with methanol (200 mL) and cool to 0-10°C. Under stirring, slowly add a mixed solution of hydrazine hydrate (138 g) and water (20 mL). The reaction mixture was gradually heated to 55-60°C and stirred continuously at this temperature for 24 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Isopropanol was added to the residue and the mixture was cooled to 0-5°C and stirred for 2 hours. The solid product was collected by filtration, washed with isopropanol and dried to give formylhydrazine. Yield: 140 g. | [Purification Methods]
Recrystallise it from EtOH and dry it in vacuo. Store below 10o; it may disproportionate on storage to 1,2-diformyl hydrazine and hydrazine. It forms a blue [Cu(CH4N2O)]SO4 salt with CuSO4. [Beilstein 2 H 93, 2 III 127, 2 IV 85.] | [References]
[1] Chemistry of Heterocyclic Compounds, 2006, vol. 42, # 2, p. 233 - 245
[2] Synthesis, 2006, # 9, p. 1504 - 1512
[3] Chemistry - An Asian Journal, 2012, vol. 7, # 4, p. 715 - 724
[4] Gazzetta Chimica Italiana, 1894, vol. 24 II, p. 225
[5] Journal of pharmaceutical sciences, 1970, vol. 59, # 1, p. 105 - 107 |
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