ChemicalBook--->CAS DataBase List--->370-81-0

370-81-0

370-81-0 Structure

370-81-0 Structure
IdentificationMore
[Name]

Bis(cyclohexanone)oxaldihydrazone
[CAS]

370-81-0
[Synonyms]

BIS(CYCLOHEXANONE) OXALDIHYDRAZONE
BISCYCLOHEXANONE OXALYLDIHYDRAZONE
BIS(CYCLOHEXYLIDENE)OXALODIHYDRAZIDE
CUPFERAZONE
CUPRIZON
CUPRIZON 1
CUPRIZONE
CUPRIZONE I
CUPRIZON I
DICYCLOHEXANONE OXALYLDIHYDRAZONE
OXALIC ACID BIS(CYCLOHEXYLIDENEHYDRAZIDE)
TIMTEC-BB SBB008866
biscyclohexanone
biscyclohexanoneoxadihydrazone
Dicyclohexanoneoxalyldihydrazo
dicyclohexanoneoxalyldihydrozone
ethanedioicacid,bis(cyclohexylidenehydrazide)
Oxalybis(cyclohexylidene hydrazone)
N,N-oxalylbis(cyclohexanone hydrazone)
oxalic bis(cyclohexylidenehydrazide)
[EINECS(EC#)]

206-729-2
[Molecular Formula]

C14H22N4O2
[MDL Number]

MFCD00001659
[Molecular Weight]

278.35
[MOL File]

370-81-0.mol
Chemical PropertiesBack Directory
[Appearance]

white powder
[Melting point ]

210-214 °C(lit.)
[Boiling point ]

421.17°C (rough estimate)
[bulk density]

150kg/m3
[density ]

1.0823 (rough estimate)
[refractive index ]

1.6200 (estimate)
[storage temp. ]

2-8°C
[solubility ]

acetic acid: 50mg/mL, colorless to very faintly brown
[form ]

Powder
[pka]

10.78±0.20(Predicted)
[color ]

White
[Water Solubility ]

Soluble in alcohol. Insoluble in water.
[BRN ]

2388004
[InChI]

1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
[InChIKey]

DSRJIHMZAQEUJV-UHFFFAOYSA-N
[SMILES]

O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2
[CAS DataBase Reference]

370-81-0(CAS DataBase Reference)
[EPA Substance Registry System]

370-81-0(EPA Substance)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H335-H315-H319
[Precautionary statements ]

P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
[Hazard Codes ]

Xn
[Risk Statements ]

R21/22:Harmful in contact with skin and if swallowed .
[Safety Statements ]

S24/25:Avoid contact with skin and eyes .
S2:Keep out of the reach of children .
[WGK Germany ]

3
[RTECS ]

RO2520000
[TSCA ]

Yes
[HS Code ]

29280090
[Storage Class]

11 - Combustible Solids
[Safety Profile]

Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also OXALATES.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Bis(cyclohexanone)oxaldihydrazone(370-81-0).msds
Hazard InformationBack Directory
[Chemical Properties]

white powder
[Uses]

Bis(cyclohexanone) oxaldihydrazone is used in the quantitative spectroscopic determination of copper. It is also essential for the experimental study of mitochondrial metabolism. It is used to study the human demyelinating diseases such as multiple sclerosis and components of neuroinflammation. Further, it acts as ligand and catalyzes Ullmann-type C-N bond forming reactions in the presence of copper salt.
[Definition]

ChEBI: Cuprizon is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.
[Biological Activity]

Bis(cyclohexanone)oxaldihydrazone (Cuprizone) is a copper chelator. It results in oligodendroglial cell deaththereby leading to demyelinationastrogliosis and microglia activation. Cuprizone is widely used to study mitochondrial dysfunction-associated primary demyelination and remyelination in the corpus callosum.
Spectrum DetailBack Directory
[Spectrum Detail]

Bis(cyclohexanone)oxaldihydrazone(370-81-0)MS
Bis(cyclohexanone)oxaldihydrazone(370-81-0)1HNMR
Bis(cyclohexanone)oxaldihydrazone(370-81-0)13CNMR
Bis(cyclohexanone)oxaldihydrazone(370-81-0)IR1
Bis(cyclohexanone)oxaldihydrazone(370-81-0)IR2
Bis(cyclohexanone)oxaldihydrazone(370-81-0)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Oxalic acid bis(cyclohexylidenehydrazide), 98%(370-81-0)
[Alfa Aesar]

Bis(cyclohexanone) oxaldihydrazone, 98%(370-81-0)
[Sigma Aldrich]

370-81-0(sigmaaldrich)
[TCI AMERICA]

Bis(cyclohexanone) Oxalyldihydrazone,>98.0%(N)(370-81-0)
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