| Identification | Back Directory | [Name]
Filociclovir | [CAS]
632325-71-4 | [Synonyms]
MBX-400
ZSM-I-62
Filociclovir
Cyclopropavir
Cyclopropavir (CPV, ZSM-I-62, MBX 400)
2-amino-9-[(Z)-[2,2-bis(hydroxymethyl)cyclopropylidene]methyl]-1H-purin-6-one | [Molecular Formula]
C11H13N5O3 | [MDL Number]
MFCD28902247 | [MOL File]
632325-71-4.mol | [Molecular Weight]
263.25 |
| Chemical Properties | Back Directory | [Boiling point ]
628.1±65.0 °C(Predicted) | [density ]
1.83±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.58±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Cyclopropavir (Filociclovir; ZSM-I-62; MBX-400) is a broad-spectrum anti-herpesvirus compound, has good antiviral activity against cytomegalovirus (CMV), herpes simplex virus (HHV)-6 and HHV-8 with EC50s of 0.7 μM to 8 μM[1]. | [References]
[1] Kern ER, et al. In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication. Antimicrob Agents Chemother. 2005 Mar;49(3):1039-45. DOI:10.1128/AAC.49.3.1039-1045.2005 |
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