| Identification | More | [Name]
4-Methylphenylhydrazine hydrochloride | [CAS]
637-60-5 | [Synonyms]
4-METHYLPHENYLHYDRAZINE HCL
4-METHYLPHENYLHYDRAZINE HYDROCHLORIDE
4-TOLYLHYDRAZINE HCL
4-TOLYLHYDRAZINE HYDROCHLORIDE
P-METHYLPHENYLHYDRAZINE HYDROCHLORIDE
P-TOLYL HYDRAZINE HCL
P-TOLYLHYDRAZINE HYDROCHLORIDE
(4-Methylphenyl)hydrazinemonohydrochloride
(4-methylphenyl)-hydrazinmonohydrochloride
p-tolyl-hydrazinhydrochloride
p-tolylhydrazinium(1+) chloride
P(4)-tolylhydrazine hydrochoride
1-(4-methylphenyl)hydrazine hydrochloride
Tolyl Hydrazine Hcl
p-Tolylhydrazinehydrochloride,98%
-METHYL PHENYL HYDRAZINE HYDROCHLORIDE
4-Methylphenylhydrazine hydrochloride 98%
HYDRAZINE,PARA-TOLYL,HYDROCHLORIDE
PARA-TOLYLHYDRAZINEHCL
p-tolyhydrazine hydrochloride | [EINECS(EC#)]
211-295-2 | [Molecular Formula]
C7H11ClN2 | [MDL Number]
MFCD00012940 | [Molecular Weight]
158.63 | [MOL File]
637-60-5.mol |
| Chemical Properties | Back Directory | [Appearance]
off-white to beige-brownish flaky powder | [Melting point ]
>200 °C (dec.)(lit.) | [Boiling point ]
217.6°C (rough estimate) | [density ]
0.9532 (rough estimate) | [refractive index ]
1.6230 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO, Methanol | [form ]
Flaky Powder | [color ]
Off-white to beige-brownish | [Water Solubility ]
soluble | [Detection Methods]
AT | [Merck ]
9542 | [BRN ]
3563996 | [InChI]
1S/C7H10N2.ClH/c1-6-2-4-7(9-8)5-3-6;/h2-5,9H,8H2,1H3;1H | [InChIKey]
HMHWNJGOHUYVMD-UHFFFAOYSA-N | [SMILES]
Cl.Cc1ccc(NN)cc1 | [CAS DataBase Reference]
637-60-5(CAS DataBase Reference) | [Storage Precautions]
Heat sensitive | [EPA Substance Registry System]
637-60-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
MW0195000
| [Hazard Note ]
Harmful/Irritant | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29280090 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Acute 1
Aquatic Chronic 1
Carc. 1B
Skin Sens. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
off-white to beige-brownish flaky powder | [Uses]
4-Tolylhydrazine Monohydrochloride has shown tumorigenic potential through studies. In addition, due to its hydrazine moiety, it has anti-cancer potential and is a compound from which derivatives are
made in the search of novel anticancer drugs. | [Uses]
4-Tolylhydrazine Monohydrochloride has shown tumorigenic potential through studies. In addition, due to its hydrazine moiety, it has anti-cancer potential and is a compound from which derivatives are made in the search of novel anticancer drugs. | [Synthesis]
General procedure for the synthesis of 4-methylphenylhydrazine hydrochloride from 4-methylaniline: 4-methylaniline (10.7 g, 0.1 mol) was mixed with dilute hydrochloric acid in a 200 ml round bottom flask. Sodium nitrite solution (30 ml, 7.3 g, 0.105 mol) was added slowly and dropwise to the above mixture. The reaction mixture was stirred for 1 hour and then filtered. The filtered clear liquid was added dropwise to 70 ml of aqueous solution containing sodium sulfite (37.8 g, 0.3 mol) and reacted at 80°C for about 1.5 hours. Subsequently, concentrated hydrochloric acid (25 ml, 0.3 mol) was added slowly and the reaction temperature was raised to 95°C and the reaction continued for about 2.5 hours. Upon completion of the reaction, the mixture was allowed to stand at room temperature overnight to precipitate 4-methylphenylhydrazine hydrochloride as a solid. After filtration and drying, 12.9 g of product was obtained in 90.0% yield. | [References]
[1] Patent: CN108623511, 2018, A. Location in patent: Paragraph 0021
[2] Patent: EP2157088, 2010, A1. Location in patent: Page/Page column 41-42
[3] Russian Chemical Bulletin, 2005, vol. 54, # 10, p. 2417 - 2424
[4] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 5, p. 1706 - 1712 |
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