| Identification | Back Directory | [Name]
Mal-PEG2-amine | [CAS]
660843-22-1 | [Synonyms]
Mal-PEG2-NH2
Mal-PEG2-amine
Mal-PEG2-amine TFA salt
1-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]maleimide
1H-?Pyrrole-?2,?5-?dione, 1-?[2-?[2-?(2-?aminoethoxy)?ethoxy]?ethyl]?- | [Molecular Formula]
C10H16N2O4 | [MOL File]
660843-22-1.mol | [Molecular Weight]
228.24 |
| Chemical Properties | Back Directory | [Boiling point ]
379.9±27.0 °C(Predicted) | [density ]
1.226±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
8.74±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Mal-PEG2-amine TFA salt is a PEG linker containing a maleimide group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Uses]
Mal-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Nextpeptide Inc
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| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
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