| Identification | Back Directory | [Name]
Ru 24969 | [CAS]
66611-27-6 | [Synonyms]
RU 24969 hemisuccinate >=98% (HPLC)
5-Methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole succinate (2:1)
1H-Indole, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, succinate (2:1)
1H-Indole, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, butanedioate (2:1)
Butanedioic acid, compd. with 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (1:2)
Butanedioic acid, compd. with5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (1:2)OTHER CA INDEX NAMES:1H-Indole, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, butanedioate(2:1) | [Molecular Formula]
C32H38N4O6 | [MDL Number]
MFCD09878262 | [MOL File]
66611-27-6.mol | [Molecular Weight]
574.667 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: slightly soluble,DMSO: slightly soluble,Ethanol: slightly soluble,PBS (pH 7.2): 1 mg/ml | [form ]
A crystalline solid | [color ]
yellow to yellow-orange | [Water Solubility ]
H2O: 2mg/mL, clear (warmed) | [InChI]
1S/2C14H16N2O.C4H6O4/c2*1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10;5-3(6)1-2-4(7)8/h2*2-4,8-9,15-16H,5-7H2,1H3;1-2H2,(H,5,6)(H,7,8) | [InChIKey]
BNYJLRQAWCQJOM-UHFFFAOYSA-N | [SMILES]
COC1=CC2=C(NC=C2C3=CCNCC3)C=C1.OC(CCC(O)=O)=O.COC4=CC5=C(NC=C5C6=CCNCC6)C=C4 |
| Hazard Information | Back Directory | [Uses]
RU 24969 Succinate (2:1), is a SR-1A and SR-1B, and moderate SR-2C agonist. 5-HT1B/1A agonist. Also, it is a well-established substrate for human serotonin transporter (SERT). | [Biological Activity]
RU-24969 is a potent and selective agonist at the 5-HT1A and 5-HT1B receptors. | [in vivo]
RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1].
RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1]. | Animal Model: | Male Sprague-Dawley rats[1] | | Dosage: | 0.03, 0.3, 1.0, 3.0 mg/kg | | Administration: | A single s.c. | | Result: | Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg. |
| [IC 50]
5-HT1B Receptor: 0.38 nM (Ki); 5-HT1A Receptor: 2.5 nM (Ki) | [storage]
Store at RT |
|
| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
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www.sigmaaldrich.cn |
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