| Identification | Back Directory | [Name]
m-PEG7-4-nitrophenyl carbonate | [CAS]
678150-56-6 | [Synonyms]
m-PEG7-4-nitrophenyl carbonate
2,5,8,11,14,17,20-Heptaoxaheneicosanoic acid, 4-nitrophenyl ester | [Molecular Formula]
C20H31NO11 | [MOL File]
678150-56-6.mol | [Molecular Weight]
461.46 |
| Hazard Information | Back Directory | [Description]
m-PEG7-4-nitrophenyl carbonate is a PEG linker with a nitrophenyl carbonate group. The nitrophenyl carbonate is a good leaving group and can react with the amine groups of lysine residue by forming a stable urethan linkage. | [Uses]
m-PEG7-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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