| Identification | Back Directory | [Name]
3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- | [CAS]
70678-95-4 | [Synonyms]
HO-PEG4-CH2COOH
Hydroxy-PEG4-CH2CO2H
Hydroxy-PEG4-CH2CO2H, sodium salt
3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]aceticacid | [Molecular Formula]
C10H20O7 | [MDL Number]
MFCD30730373 | [MOL File]
70678-95-4.mol | [Molecular Weight]
252.26 |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG4-CH2CO2H, sodium salt, is a PEG derivative containing a hydroxyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | [Uses]
Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
|
|