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71277-17-3

71277-17-3 Structure

71277-17-3 Structure
IdentificationBack Directory
[Name]

N1,N1'-(1,4-phenylenebis(methylene))bis(N1-(2-aminoethyl)ethane-1,2-diamine) HCl salt
[CAS]

71277-17-3
[Synonyms]

Benzenedimethanamine-diethylamine
1,4-Benzenedimethanamine, N1,N1,N4,N4-tetrakis(2-aminoethyl)-
N1,N1'-(1,4-phenylenebis(methylene))bis(N1-(2-aminoethyl)ethane-1,2-diamine) HCl salt
[Molecular Formula]

C16H32N6
[MDL Number]

MFCD28142456
[MOL File]

71277-17-3.mol
[Molecular Weight]

308.47
Chemical PropertiesBack Directory
[Boiling point ]

425.0±40.0 °C(Predicted)
[density ]

1.088±0.06 g/cm3(Predicted)
[pka]

10.12±0.10(Predicted)
Hazard InformationBack Directory
[Description]

N1,N1'-(1,4-phenylenebis(methylene))bis(N1-(2-aminoethyl)ethane-1,2-diamine) HCl salt contains four free amine groups that are able to react with carboxylic acids, activated NHS esters and other carbonyl groups.
[Uses]

Benzenedimethanamine-diethylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

Alkyl-Chain
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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