| Identification | Back Directory | [Name]
(+)-Lupanine perchlorate | [CAS]
7400-11-5 | [Synonyms]
(+)-Lupanine perchlorate | [Molecular Formula]
C15H25ClN2O5 | [MDL Number]
MFCD32264065 | [MOL File]
7400-11-5.mol | [Molecular Weight]
348.82 |
| Chemical Properties | Back Directory | [Melting point ]
204-205 °C | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Very Slightly, Sonicated) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
(+)-Lupanine is used in biological studies with quinolizidine alkaloids in seeds of lupin genotypes of different origins. | [in vivo]
Lupanine (100-300 mg/kg for i.p.; 175-700 mg/kg for p.o.) is much less toxic in one single injection in EOPS male Swiss mice (20-22 g) and Hartley guinea-pigs (400-500 g)[1].
Lupanine (1-7.5 mg/kg; i.v.) is more efficient than Sparteine for antagonizing secondary reflex hypertension in carotid occlusion and hypotension resulting from the stimulation of the pneumogastric nerve in both the cat and the dog[1].
Lupanine has an inhibitory action on nicotinic type hypertension produced by injection of Acetylcholine (500 p.g/kg i.v.) in the Atropine-treated dog[1].
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