| Identification | Back Directory | [Name]
mPEG6-CH2COOH | [CAS]
75427-75-7 | [Synonyms]
mPEG6-CH2COOH
m-PEG6-O-CH2COOH
3,6,9,12,15,18,21-Heptaoxadocosanoic acid
2,5,8,11,14,17,20-heptaoxadocosan-22-oicacid | [Molecular Formula]
C15H30O9 | [MDL Number]
MFCD30536159 | [MOL File]
75427-75-7.mol | [Molecular Weight]
354.39 |
| Chemical Properties | Back Directory | [Boiling point ]
455.8±40.0 °C(Predicted) | [density ]
1.123±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
3.39±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
m-PEG7-CH2COOH is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG6-O-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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