| Identification | More | [Name]
TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE | [CAS]
77279-24-4 | [Synonyms]
1-BOC-4-(2-HYDROXYETHYL)-PIPERAZINE
1-(TERT-BUTOXYCARBONYL)-4-(2-HYDROXYETHYL)PIPERAZINE
4-(2-HYDROXYETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
4-(2-HYDROXYETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
BOC-N-(2-HYDROXYETHYL)PIPERAZINE
BUTTPARK 46\04-31
TERT-BUTYL 4-(2-HYDROXYETHYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
1-TERT-BUTYLOXY CARBONYL-4-HYDROXYETHYL PIPERAZINE
N-Boc-N’-(2-hydroxyethyl)-piperazine
4-(2-Hydroxyethyl)piperazine, N1-BOC protected
tert-Butyl 4-(2-hydroxyethyl)piperazine-1- | [Molecular Formula]
C11H22N2O3 | [MDL Number]
MFCD00728947 | [Molecular Weight]
230.3 | [MOL File]
77279-24-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
38-42 °C | [Boiling point ]
114°C 0,1mm | [density ]
1.092±0.06 g/cm3(Predicted) | [Fp ]
110 °C | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
14.96±0.10(Predicted) | [color ]
White to pale brown | [InChI]
InChI=1S/C11H22N2O3/c1-11(2,3)16-10(15)13-6-4-12(5-7-13)8-9-14/h14H,4-9H2,1-3H3 | [InChIKey]
VRXIOAYUQIITBU-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCN(CCO)CC1 | [CAS DataBase Reference]
77279-24-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C,N,T | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R50:Very Toxic to aquatic organisms.
R25:Toxic if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1/PG 3 | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [PackingGroup ]
Ⅲ | [HS Code ]
2933599590 | [Storage Class]
6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Acute 1 |
| Hazard Information | Back Directory | [Uses]
Boc-Piperazine-OH is a PROTAC Linker in SJ46420 (HY-168635)[1]. | [Synthesis]
General procedure: synthesis of tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (57): 1-(2-hydroxyethyl)piperazine (3.0 g, 23.0 mmol) was dissolved in dry tetrahydrofuran (THF) under nitrogen protection. Subsequently, di-tert-butyl dicarbonate (5.5 g, 25.3 mmol) was slowly added to this solution. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was evaporated to half of the initial volume by rotary evaporator. The concentrated mixture was poured into deionized water and extracted with dichloromethane (CH2Cl2). The organic phases were combined, washed with saturated saline and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the filtrate was concentrated under reduced pressure to afford the light yellow oily product tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (5.3 g, quantitative yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 1.46 (s, 9H), 2.44-2.46 (m, 4H), 2.54-2.57 (m, 2H), 2.66 (m, J = 5.3 Hz, 1H), 3.42-3.45 (m, 4H), 3.62 (q, J = 5.3 Hz, 2H). | [References]
[1] Scott DC, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. DOI:10.1038/s41467-024-52966-3 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
AllyChem Co., Ltd.
|
| Telephone: |
0411-62313318 13889470786 |
| Website: |
www.chemicalbook.com/showsupplierproductslist677/0_en.htm |
|