| Identification | More | [Name]
4-Methyl-2-oxovaleric acid | [CAS]
816-66-0 | [Synonyms]
2-KETO-4-METHYL-N-PENTANOIC ACID
2-KETO-4-METHYLPENTANOIC ACID
2-KETO-ISO-CAPROIC ACID
2-KETO-ISO-HEXANOIC ACID
2-OXO-4-METHYLVALERIC ACID
2-OXOISOCAPROIC ACID
4-METHYL-2-OXOPENTANOIC ACID
4-METHYL-2-OXOVALERIC ACID
A-KETOISOCAPROIC ACID
ALPHA-KETOISOCAPROIC ACID
KETOLEUCINE
2-keto-isocaproate
4-methyl-2-oxo-pentanoicaci
Isopropylpyruvicacid
Pentanoic acid, 4-methyl-2-oxo-
4-METHYL-2-OXOVALERIC ACID 95+%
ALPHA-KETOLEUCINE
2-Oxoisocaproic acid, 4-Methyl-2-oxopentanoic acid, Ketoleucine
2-Oxo-4-methylpentanoic acid | [EINECS(EC#)]
212-435-5 | [Molecular Formula]
C6H10O3 | [MDL Number]
MFCD00066204 | [Molecular Weight]
130.14 | [MOL File]
816-66-0.mol |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 3
| [WGK Germany ]
3
| [F ]
3-9-13 | [TSCA ]
Yes | [HS Code ]
2918.30.9000 | [HazardClass ]
8 | [PackingGroup ]
III |
| Hazard Information | Back Directory | [Occurrence]
Reported found in banana, asparagus, cheese, white wine, cocoa, blue cheese and provolone cheese. | [Uses]
4-Methyl-2-oxovaleric acid is an intermediate in the metabolism of leucine and also used as flavoring agents. | [Definition]
ChEBI: A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease. | [in vivo]
4-Methyl-2-oxopentanoic acid (4 mol/L; ICV; 1 h and 15 d) causes impairment of habitual memory and long-term memory in rats[3].
4-Methyl-2-oxopentanoic acid (400 μmol/kg/h; carotid arch injection; single dose injection 60 min) increases porcine skeletal muscle protein synthesis and plasma leucine levels[4]. | Animal Model: | Thirty-day-old rats were anesthetized with a mixture of ketamine and xylazine (HY-B0443)[3] | | Dosage: | 4 mol/L, Administer 2 μL | | Administration: | Intracerebroventricular injection (ICV); 1 h and 15 days | | Result: | Increased TBARS levels, protein carbonyl content and DNA damage in the hippocampus, striatum and cerebral cortex.
SOD activity in the hippocampus and striatum increased 1 hour after injection, and SOD activity in the striatum decreased 15 days later.
|
| Animal Model: | Piglets were deprived of feed for 12-14 hours before infusion[4] | | Dosage: | 400 μmol/kg | | Administration: | Inject into the aortic arch; the initial injection dose is 148 μmol/kg in the first 10 minutes, and the continuous infusion dose is 400 μmol/kg | | Result: | Increased phosphorylation of eukaryotic initiation factor (eIF) 4E binding protein-1 (4E-BP1) and eIF4G in skeletal muscle and increased the formation of active eIF4G×eIF4E complexes. |
| [IC 50]
Human Endogenous Metabolite |
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