| Hazard Information | Back Directory | [Uses]
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1]. | [Biological Activity]
PF-00356231 hydrochloride is a non-peptide, non-zinc-chelating matrix metalloprotease MMP-12 ligand and inhibitor (IC50=1.4 μM). It is specific for MMP-12 and forms the PF-00356231/MMP-12 complex. | [in vitro]
PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). It decreases the IC 50 values of MMP-12 ( 0.014 μM) and MMP-13 (0.27 μM) in the presence AH. | [target]
| MMP-12 < span> 1.4 μM (IC 50 ) | MMP13 0.65 nM (IC 50 ) | MMP-3 < span> 0.39 μM (IC 50 ) | MMP-8 1.7 μM (IC 50 ) | MMP-9 0.98 μM (IC 50 ) | | [IC 50]
MMP-12: 1.4 μM (IC50); MMP13: 0.65 nM (IC50); MMP-3: 0.39 μM (IC50); MMP-8: 1.7 μM (IC50); MMP-9: 0.98 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76. DOI:10.1016/j.jmb.2004.06.039 |
|
|