| Identification | Back Directory | [Name]
ML335 | [CAS]
825658-06-8 | [Synonyms]
TREK-1/2 Activator
ML335; ML-335; ML 335; TREK-1/2 ACTIVATOR
Benzamide, N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]- | [Molecular Formula]
C15H14Cl2N2O3S | [MDL Number]
MFCD06003481 | [MOL File]
825658-06-8.mol | [Molecular Weight]
373.25 |
| Chemical Properties | Back Directory | [storage temp. ]
-20° | [solubility ]
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming). | [form ]
solid | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| Hazard Information | Back Directory | [Description]
Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1?It represents an important new pharmacological tool for studying the physiology of TREK channels. | [Uses]
ML335, is a selective activator of both TREK-1 and TREK-2. | [storage]
Store at +4°C | [References]
1) Lolicato?et al.?(2017),?K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature,?547?364 |
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