| Identification | More | [Name]
1-Adamantanecarboxylic acid | [CAS]
828-51-3 | [Synonyms]
1-ADAMANTANECARBOXYLIC ACID
1-ADAMANTOIC ACID
ADAMANTANE-1-CARBOXYLIC ACID
AKOS BC-0655
LABOTEST-BB LT00436929
OTAVA-BB BB0111370036
RARECHEM AQ TC 1001
Tricyclo[3.3.1.1(3,7)]decan-1-Carboxylic acid
TRICYCLO[3.3.1.1(3,7)]DECANE-1-CARBOXYLIC ACID
TRICYCLO[3.3.1.1]DECANE-1-CARBOXYLIC ACID
1-Carboxyadamantane
3-Adamantanecarboxylic acid
3-adamantanecarboxylicacid
adamantanecarboxylic acid
Adamantoic acid
ricyclo[3.3.1.13,7]decane-1-carboxylic acid
Tricyclo[3.3.1.13,7]-decane-1-carboxylic acid
1-Adamantan Carboxylic Acid
1-adamantylmethanoic acid
1-Adamantanecarboxylic | [EINECS(EC#)]
212-584-6 | [Molecular Formula]
C11H16O2 | [MDL Number]
MFCD00074720 | [Molecular Weight]
180.24 | [MOL File]
828-51-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white to off-white crystalline powder | [Melting point ]
172-174 °C (lit.) | [Boiling point ]
253.08°C (rough estimate) | [density ]
0.9976 (rough estimate) | [refractive index ]
1.4910 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform, Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
4.86±0.20(Predicted) | [color ]
White to off-white | [Water Solubility ]
Insoluble in water. Solubility in methanol gives very faint turbidity. Soluble in ethanol, chloroform, and dichloromethane. | [Detection Methods]
T,NMR | [BRN ]
1910637 | [InChI]
InChI=1S/C11H16O2/c12-10(13)11-4-7-1-8(5-11)3-9(2-7)6-11/h7-9H,1-6H2,(H,12,13) | [InChIKey]
JIMXXGFJRDUSRO-UHFFFAOYSA-N | [SMILES]
C12(C(O)=O)CC3CC(CC(C3)C1)C2 | [CAS DataBase Reference]
828-51-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Adamantane-1-carboxylic acid(828-51-3) |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white crystalline powder | [Uses]
Adamantoic Acid is an inhibitor of chorismate mutase activity and hydroxyphenylpyruvate synthase. It inhibits TTR conformational changes facilitating amyloid fibril formation. | [Synthesis Reference(s)]
Synthetic Communications, 18, p. 545, 1988 DOI: 10.1080/00397918808060749 | [Biochem/physiol Actions]
1-Adamantanecarboxylic acid undergoes complexation reactions with cyclohexaamylose. It is an inhibitor of phenyl ester hydrolysis of cycloheptaamylose. | [Purification Methods]
Possible impurities are trimethylacetic acid and C9 and C13 acids. Dissolve 15g of the acid in CCl4 (300mL) and shake with 110mL of 15N aqueous NH3 whereby the ammonium salt separates and is collected. Acid impurities form soluble ammonium salts. The salt is washed with cold Me2CO (20mL) and suspended in H2O (250mL). This is treated with 12N HCl and extracted with CHCl3 (100mL). The dried (Na2SO4) extract was evaporated and the residue was recrystallised from a mixture of MeOH (30mL) and H2O (ca 10mL) to give the pure acid (10-11g). [Koch & Haaf Org Synth Coll Vol V 20 1973.] It was also recrystallised from absolute EtOH and dried under vacuum at 100o. Alternatively, the acid (5g) is refluxed for 2hours with 15mL of MeOH and 2mL of 98% H2SO4 (cool when mixing this solution). Pour into 10 volumes of H2O and extract with the minimum volume of CHCl3 to give clear separation of phases. The extract is washed with H2O, dried (CaCl2) and distilled. The methyl ester is collected at 77-79o/1mm, m 38-39o. The ester is hydrolysed with the calculated amount of N KOH and refluxed until clear. Acidification with HCl provides the pure acid with 90% recovery. The amide crystallises from cyclohexane, m 189o. [Stetter et al. Chem Ber 92 1629 1959.] [Beilstein 9 IV 253.] |
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