| Identification | More | [Name]
2-Butyl-4-chloro-5-formylimidazole | [CAS]
83857-96-9 | [Synonyms]
2-BUTYL-4(5)-CHLORO-5(4)IMIDAZOLECARBOXALDEHYDE
2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBALDEHYDE
2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBOXALDEHYDE
2-BUTYL-4-CHLORO-5-FORMYLIMIDAZLOE
2-BUTYL-4-CHLORO-5-FORMYLIMIDAZOLE
2-BUTYL-4-CHLORO-IMIDAZOLE-5-CARBALDEHYDE
2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBALDEHYDE
2-BUTYL-5-CHLORO-1H-IMIDAZOLE-4-CARBOXALDEHYDE
2-BUTYL-5-CHLOROIMIDAZOLE-4-CARBOXALDEHYDE
2-N-BUTYL-4(5)-CHLORO-1H-IMIDAZOLE-5(4)-CARBOXALDEHYDE
2-N-BUTYL-4-CHLORO-5-FORMYLIMIDAZOLE
2-N-BUTYL-4-CHLOROIMIDAZOLE-5-CARBOXALDEHYDE
2-N-BUTYL-5-CHLORO-4-FORMYL IMIDAZOLE
2-Butyl-5-chloro-1H-imidazole carboxaldehyde
2-Butyl-4(5)-chloro-5(4)-imidazolecarboxyaldehyde
2-n-butyl-4(5)-Chloro-1H-imdazole-5(4)-carboxaldehyde
2-Butyl-5-chloro-4-formylimidazole
2-Butyl-5-choloro-1H-imidazole-4-carbaldehyde
2-Butyl-4-chloro-5-imidazolecarboxaldehyde
2-Butyl-5-Chloro-1H-Imidagole-4-Carbaldehyde | [EINECS(EC#)]
410-260-0 | [Molecular Formula]
C8H11ClN2O | [MDL Number]
MFCD01934396 | [Molecular Weight]
186.64 | [MOL File]
83857-96-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Solid | [Melting point ]
97-100 °C(lit.)
| [Boiling point ]
384.1±22.0 °C(Predicted) | [density ]
1.240 | [vapor pressure ]
0.001Pa at 25℃ | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
slightly soluble | [form ]
neat | [pka]
8.87±0.10(Predicted) | [color ]
Pale Yellow to Brown | [Water Solubility ]
slightly soluble | [Detection Methods]
HPLC,NMR | [InChI]
1S/C8H11ClN2O/c1-2-3-4-7-10-6(5-12)8(9)11-7/h5H,2-4H2,1H3,(H,10,11) | [InChIKey]
JLVIHQCWASNXCK-UHFFFAOYSA-N | [SMILES]
CCCCc1nc(C=O)c(Cl)[nH]1 | [LogP]
2.5 at 25℃ and pH7.1 | [Surface tension]
58.3mN/m at 1.2g/L and 20℃ | [CAS DataBase Reference]
83857-96-9(CAS DataBase Reference) | [EPA Substance Registry System]
83857-96-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,N | [Risk Statements ]
R43:May cause sensitization by skin contact.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S24:Avoid contact with skin .
S37:Wear suitable gloves .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 3077 9/PG 3 | [WGK Germany ]
2 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Chronic 2
Skin Sens. 1A |
| Hazard Information | Back Directory | [Description]
2-Butyl-4-chloro-5-formylimidazole(83857-96-9) is an API intermediate used as an intermediate for the anti-hypertensive drug Chlosartan. It can be used in the chemical manufacture of many APIs and advanced intermediates. With the help of this chemical, a number of other chemicals can be manufactured that have further applications in industries such as Losartan manufacturing.
| [Chemical Properties]
2-Butyl-4-chloro-5-formylimidazole is Yellow Solid
| [Uses]
2-Butyl-4-chloro-5-formylimidazole(83857-96-9) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists
| [Application]
2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D,83857-96-9) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A.
| [Synthesis Reference(s)]
The Journal of Organic Chemistry, 64, p. 8084, 1999 DOI: 10.1021/jo9824910 | [Synthesis]
2-Butyl-4-chloro-5-formylimidazole(83857-96-9) was synthesised as follows: Performing condensation reaction of pentamidine hydrochloride with glyoxal and controlling the pH value of the system in the range of 6.0-7.5; after the reaction terminates, arousing dehydration reaction of the compound of formula III, thereby obtaining 2-butyl-1H-imidazole-5(4H)-ketone; and finally, reacting 2-butyl-1H-imidazole-5(4H)-ketone with N,N-dimethylformamide in the presence of phosphorus oxychloride, thereby obtaining 2-butyl-4-chloro-5-formylimidazole.
| [storage]
2-Butyl-4-chloro-5-formylimidazole is soluble in DMF, DMSO, Ethanol and Methanol. |
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