| Identification | More | [Name]
Isobutaneboronic acid | [CAS]
84110-40-7 | [Synonyms]
1-ISOBUTANEBORONIC ACID
2-METHYL-1-PROPANEBORONIC ACID
2-METHYL-1-PROPYLBORONIC ACID
(2-METHYLPROPYL)BORONIC ACID
ISOBUTYLBORONIC ACID
RARECHEM AH PB 0258
2-Methylprop-1-ylboronic acid
Isobutylboronic
isobutaneboronic acid
ISOBUTYLBORONIC ACID, CONTAINS VARYING AMOUNTS OF ANHYDRIDE
2-Methylpropaneboronic acid | [EINECS(EC#)]
617-531-4 | [Molecular Formula]
C4H11BO2 | [MDL Number]
MFCD00134156 | [Molecular Weight]
101.94 | [MOL File]
84110-40-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white flake | [Melting point ]
108-111 °C(lit.)
| [Boiling point ]
180.0±23.0 °C(Predicted) | [density ]
0.910±0.06 g/cm3(Predicted) | [storage temp. ]
0-6°C | [solubility ]
Acetonitrile (Slightly), DMSO, Methanol (Slightly) | [form ]
Crystalline Powder or Flakes | [pka]
10.49±0.43(Predicted) | [color ]
White to cream | [InChI]
InChI=1S/C4H11BO2/c1-4(2)3-5(6)7/h4,6-7H,3H2,1-2H3 | [InChIKey]
ZAZPDOYUCVFPOI-UHFFFAOYSA-N | [SMILES]
B(CC(C)C)(O)O | [CAS DataBase Reference]
84110-40-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
No | [HazardClass ]
IRRITANT | [HS Code ]
29319099 | [Storage Class]
11 - Combustible Solids |
| Questions And Answer | Back Directory | [Description]
Isobutaneboronic acid is also known as isobutylboronic acid. Isobutaneboronic acid has been used to synthesize potent and selective dipeptidyl boronic acid proteasome inhibitors, which are promising therapeutics to treat cancer and inflammatory diseases.1
| [Reference]
J. Adams, M. Behnke, S. Chen, A. A. Cruickshank, L. R. Dick, L. Grenier, J. M. Klunder, Y. Ma, L. Plamondon, R. L. Stein, Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids, Bioorganic & Medicinal Chemistry Letters, 1998, vol. 8, pp. 333-338
|
| Hazard Information | Back Directory | [Chemical Properties]
white flake | [Uses]
2-Methylpropylboronic Acid is used in the preparation of isocoumarin analogs as inhibitors of γ-secretase cleavage. Also used in the preparation of peptide boronc acid. | [Uses]
suzuki reaction | [Synthesis]
In a 50 ml round-bottomed flask containing potassium 4-methoxyphenyltrifluoroborate (456 mg, 3.0 mmol) and silica gel (180 mg, 3.0 mmol), a volume of H2O (9 mL) was added rapidly under nitrogen. The reaction was stirred at room temperature until NMR indic |
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