| Identification | Back Directory | [Name]
ZK-90055 (hydrochloride) | [CAS]
84638-81-3 | [Synonyms]
ZK-90055 (hydrochloride) | [Molecular Formula]
C16H23ClN2O4 | [MDL Number]
MFCD31382090 | [MOL File]
84638-81-3.mol | [Molecular Weight]
342.82 |
| Hazard Information | Back Directory | [Uses]
ZK-90055 hydrochloride is a β2 adrenergic receptor agonist. | [in vivo]
Contrasting a pro-drug, a soft-drug is active per se when given locally but is rapidly inactivated when it reaches the general circulation. Thus, a long duration of action at a minimum of systemic side effects may be achieved after inhalation of a h2-agonist designed in this way. One such example is ZK-90055, an indol derivative with a hydrolysable ester bond on the ring system. The development of ZK-90055 is stopped before clinical trials are commenced[2]. | [storage]
Store at -20°C | [References]
[1] Waldeck B, et al. beta-Adrenoceptor agonists after terbutaline. Pharmacol Toxicol. 1995;77 Suppl 3:25-9. DOI:10.1111/j.1600-0773.1995.tb01937.x
[2] Waldeck B, et al. Beta-adrenoceptor agonists and asthma--100 years of development. Eur J Pharmacol. 2002 Jun 7;445(1-2):1-12. DOI:10.1016/s0014-2999(02)01728-4 |
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