| Identification | Back Directory | [Name]
ZK-261991 | [CAS]
886563-25-3 | [Synonyms]
ZK 991
ZK-991
ZK-261991
ZK261991(ZK991)
ZK261991;ZK-261991;ZK 261991;ZK-991;ZK 991
Benzamide, 2-[[[2-[[(dimethylamino)carbonyl]amino]-4-pyridinyl]methyl]amino]-N-(2-methyl-2H-indazol-6-yl)- | [Molecular Formula]
C24H25N7O2 | [MDL Number]
MFCD25976709 | [MOL File]
886563-25-3.mol | [Molecular Weight]
443.5 |
| Hazard Information | Back Directory | [Uses]
ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2. | [in vivo]
ZK991 results in a significantly reduced recruitment of CD11b+ and LYVE-1+ cells into the murine cornea. ZK991 significantly improves the graft survival rate after corneal transplantation[1]. | [IC 50]
VEGFR2: 5 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Deniz Hos, et al. Inflammatory Corneal (Lymph)angiogenesis Is Blocked by VEGFR-Tyrosine Kinase Inhibitor ZK 261991, Resulting in Improved Graft Survival after Corneal Transplantation. Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1836-184 |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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BOC Sciences
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cjbscvictory
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MedChemExpress
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