| Identification | Back Directory | [Name]
PMX 53 acetate(219639755 free base),PMX 53 acetate(219639 75 5 free base) | [CAS]
852629-88-0 | [Synonyms]
PMX 53 acetate
PMX 53 acetate(219639-75-5 free base)
PMX 53 acetate(219639-75-5 free base), 10 mM in DMSO
PMX 53 acetate(219639755 free base),PMX 53 acetate(219639 75 5 free base) | [Molecular Formula]
C47H65N11O7.C2H4O2 | [MOL File]
852629-88-0.mol | [Molecular Weight]
956.14 |
| Hazard Information | Back Directory | [Uses]
PMX 53 monoacetate (3D53 monoacetate) is a potent orally active CD88 (C5aR) antagonist that inhibits C5a-induced neutrophil myeloperoxide release and chemotactic activity. PMX 53 monoacetate has an IC50 value of 20 nM against C5a-induced neutrophil myeloperoxide release. >The value is 22 nM, and the IC50 value of the chemotactic activity is 75 nM. PMX 53 monoacetate is also an agonist of MrgX2[1]. | [References]
[1] PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells DOI:10.1124/mol.111.071472 |
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