| Identification | More | [Name]
3-Chloro-2-methylaniline | [CAS]
87-60-5 | [Synonyms]
2-AMINO-6-CHLOROTOLUENE
3-CHLORO-2-METHYLANILINE
3-chloro-2-methylbenzenamine
3-CHLORO-O-TOLUIDINE
6-CHLORO-2-AMINO TOLUENE
6-CHLORO-2-TOLUIDINE
6COT
AKOS BBS-00003567
Azoic Diazo Component 46
CI 37080
FAST SCARLET TR BASE
LABOTEST-BB LTBB000775
TIMTEC-BB SBB007550
1-Amino-3-chloro-2-methylbenzene
2-amino-6-chloro-toluen
2-Methyl-3-chloroaniline
3-Chlor-2-toluidin
3-chloro-2-methyl-benzenamin
3-Chloro-2-methylphenylamine
3-chloro-2-toluidin(czech) | [EINECS(EC#)]
201-756-6 | [Molecular Formula]
C7H8ClN | [MDL Number]
MFCD00007766 | [Molecular Weight]
141.6 | [MOL File]
87-60-5.mol |
| Chemical Properties | Back Directory | [Appearance]
The chloromethylanilines are colorless or
white crystalline solids or liquids, some have a mild
fishy odor. | [Melting point ]
2 °C (lit.) | [Boiling point ]
115-117 °C/10 mmHg (lit.) | [density ]
1.185 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.588(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
4.5g/l | [form ]
Liquid | [pka]
pK1:2.49(+1) (25°C) | [color ]
Clear yellow to red or red-brown | [Specific Gravity]
1.19 | [Water Solubility ]
1g/L at 20℃ | [BRN ]
471697 | [Henry's Law Constant]
6.3×100 mol/(m3Pa) at 25℃, HSDB (2015) | [InChI]
1S/C7H8ClN/c1-5-6(8)3-2-4-7(5)9/h2-4H,9H2,1H3 | [InChIKey]
ZUVPLKVDZNDZCM-UHFFFAOYSA-N | [SMILES]
Cc1c(N)cccc1Cl | [LogP]
2.4 | [CAS DataBase Reference]
87-60-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenamine, 3-chloro-2-methyl-(87-60-5) | [EPA Substance Registry System]
87-60-5(EPA Substance) |
| Questions And Answer | Back Directory | [Synthesis]
It is obtained by chlorination and reduction of o-nitrotoluene.
1. Chlorination reaction
In o-nitrotoluene, add 2% ferric chloride as a catalyst, pass chlorine gas at 50-60 ° C until the relative density of the reaction solution reaches 1.27-1.29 (50 ° C), wash with 5% hydrochloric acid, and then Wash with water, and finally adjust pH to 7 with liquid caustic soda. Divide the water layer, evaporate the water, carry out vacuum distillation, collect 120-150 ℃ (5.33-8.0kPa) fractions, crystallize by cooling and filter to obtain 2-chloro-6-nitrotoluene.
2. Reduction reaction
Add hydrochloric acid and iron powder to the reaction pot, stir and heat to 90°C, slowly add melted 2-chloro-6-nitrotoluene, complete the addition, and reflux for 3 hours. Cooling, adding liquid alkali to adjust pH to 8, steam distillation to obtain 3-chloro-o-toluidine. |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS05,GHS07,GHS08 | [Signal word ]
Danger | [Hazard statements ]
H302-H314-H334 | [Precautionary statements ]
P261-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
C,N,Xn | [Risk Statements ]
R22:Harmful if swallowed.
R34:Causes burns.
R43:May cause sensitization by skin contact.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN 3429 6.1/PG 3
| [WGK Germany ]
2
| [RTECS ]
XU4760000
| [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214300 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 4 Oral
Resp. Sens. 1
Skin Corr. 1B | [Safety Profile]
Poison by ingestion.
Mutation data reported. When heated to
decomposition it emits toxic fumes of Cl
and NOx. See also other chloro toluidine
entries. | [Hazardous Substances Data]
87-60-5(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Potential Exposure]
Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill
birds. It is marketed as pelleted bait for control of bird
populations. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
| [Shipping]
UN2239 Chlorotoluidines, solid, Hazard Class:
6.1; Labels: 6.1-Poisonous materials. UN3429
Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1-
Poisonous materials | [Incompatibilities]
Incompatible with oxidizers, strong
acids; chloroformates, and acid anhydrides, isocyanates,
aldehydes forming fire and explosive hazards. | [Description]
The chloromethylanilines are colorless orwhite crystalline solids or liquids, some have a mild fishyodor. Molecular weight (all isomers) =141.61. HazardIdentification (based on NFPA 704 M Rating System): (87-60-5) Health 2, Flammability 1, Reactivity 0. All are soluble in water and include: | [Chemical Properties]
clear yellow to red or red-brown liquid | [Chemical Properties]
The chloromethylanilines are colorless or
white crystalline solids or liquids, some have a mild
fishy odor. | [Uses]
Intermediate. | [Preparation]
By 1-Methyl-2-nitrobenzene chlorination byproducts 3-Chloro-2-methylbenzenamine?reduction. | [Hazard]
Toxic by ingestion or inhalation. | [storage]
Color Code—Blue: Health Hazard/Poison: Store ina secure poison location. Prior to working with chloromethylanilines you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, well-ventilated area. Sources of ignition, such as smoking and openflames, are prohibited where Choromethyl anilines are handled, or stored in a manner that could create a potential fireor explosion hazard. A regulated, marked area should beestablished where this chemical is handled, used, or stored incompliance with OSHA Standard 1910.1045. | [References]
[1] Materials Research Bulletin, 2013, vol. 48, # 5, p. 1885 - 1890
[2] Bulletin of the Korean Chemical Society, 2012, vol. 33, # 9, p. 2851 - 2852
[3] Patent: CN104725242, 2017, B. Location in patent: Paragraph 0026-0027
[4] Journal of the Chemical Society. Perkin Transactions 1, 2001, # 9, p. 955 - 977
[5] Synthetic Communications, 1981, vol. 11, # 11, p. 925 - 930 |
|
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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