| Identification | Back Directory | [Name]
Azido-PEG2-CH2CO2H | [CAS]
882518-90-3 | [Synonyms]
882518-90-3
N3-PEG2-CH2COOH
Azido-PEG2-CH2CO2H
Azido-PEG2-CH2COOH
AZIDE-PEG2-CH2COOH
2-[2-(2-Azidoethoxy)ethoxy]acetic acid
Acetic acid, [2-(2-azidoethoxy)ethoxy]-
N-(2-(2-(2-azidoethoxy)ethoxy))acetic acid | [Molecular Formula]
C6H11N3O4 | [MDL Number]
MFCD24395877 | [MOL File]
882518-90-3.mol | [Molecular Weight]
189.17 |
| Chemical Properties | Back Directory | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Soluble in Water | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C6H11N3O4/c7-9-8-1-2-12-3-4-13-5-6(10)11/h1-5H2,(H,10,11) | [InChIKey]
OCIIYNXOTJRSHW-UHFFFAOYSA-N | [SMILES]
C(COCC(=O)O)OCCN=[N+]=[N-] |
| Hazard Information | Back Directory | [Description]
Azido-PEG2-CH2CO2H is a water soluble click chemistry reagent containing an azide group with a terminal carboxylic acid. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Azido-PEG2-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] Yimin Qian, et al. Composés et procédés pour la dégradation ciblée de protéines contenant un bromodomaine. WO2017030814A1. |
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Shanghai UCHEM Inc.
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