| Identification | More | [Name]
DIMINAZENE ACETURATE | [CAS]
908-54-3 | [Synonyms]
BERENIL
DIMINAZENE ACETURATE
DIMINAZENE DIACETURATE
DIMINAZENE DIACTETURATE
DIMINAZINE ACETURATE
4,4’-(diamino)dibenzamidediaceturate
4,4’-(Diazoamino)dibenzamidinediaceturate
amide](2:1)
azidin
azidine
beronal
di-(4-amidinophenyl)-triazen-(n-1,3)-diaceturat
di-(4-amidinophenyl)-triazine-(n-1,3)-diaceturate
diaminazeneaceturate
ganasag
ganaseg
glycine,n-acetyl-,compd.with4,4’-(1-triazene-1,3-diyl)bis(benzenecarboxim
glycine,n-acetyl-,compd.with4,4’-(1-triazene-1,3-diyl)bis[benzenecarboximid
glycine,n-acetyl-,compd.with4,4’-(diazoamino)dibenzamidine(2:1)
idamide)(2:1) | [EINECS(EC#)]
212-999-2 | [Molecular Formula]
C22H29N9O6 | [MDL Number]
MFCD00058386 | [Molecular Weight]
515.52 | [MOL File]
908-54-3.mol |
| Chemical Properties | Back Directory | [Appearance]
solid | [Melting point ]
202 °C | [storage temp. ]
0-6°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
powder | [color ]
Orange to Dark Orange | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
Soluble to 100 mM in water | [CAS DataBase Reference]
908-54-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Diminazene is a diamidine that is cytotoxic to protozoa, including Trypanosoma, Babesia, and Cytauxzoon.1,2 Diamidines, including diminazene, affect a variety of enzymes and modulate interactions between nucleic acids and proteins.3 Diminazene inhibits diamine oxidase with a Ki value of 13 nM.3 In Trypanosoma, transport proteins are important in the effectiveness of diminazene.4 In rats and in vitro, diminazene enhances the enzymatic activity of angiotensin-converting enzyme 2.5 | [Chemical Properties]
solid | [Uses]
An anti-protozoal and anti-trypanosomal compound | [Uses]
antiprotozoal as aceturate | [Uses]
Diminazene aceturate is an anti-protozoal drug. Diminazene Diaceturate is used as an anti-trypanosomal agent.
| [Definition]
ChEBI: An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine. | [Veterinary Drugs and Treatments]
Diminazene is used to treat trypanosomiasis in dogs and livestock
(sheep, goats, cattle), Babesia infections in dogs and horses, and cytauxzoonosis
in cats. The drug is not commercially available in the
USA, but is available and used in many countries. | [storage]
Store at RT | [References]
[1] J MOSQUEDA. Current advances in detection and treatment of babesiosis.[J]. Current medicinal chemistry, 2012, 19 10: 1504-1518. DOI: 10.2174/092986712799828355
[2] GEORGE LAYLSON DA SILVA OLIVEIRA Rivelilson M de F. Diminazene aceturate—An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics[J]. Pharmacological research, 2015, 102: Pages 138-157. DOI: 10.1016/j.phrs.2015.10.005
[3] TIEN L. HUANG Jean J V E Annie Mayence. Some non-conventional biomolecular targets for diamidines. A short survey[J]. Bioorganic & Medicinal Chemistry, 2014, 22 7: Pages 1983-1992. DOI: 10.1016/j.bmc.2014.02.049
[4] JANE C MUNDAY H P de K Luca Settimo. Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei.[J]. Frontiers in Pharmacology, 2015, 6: 32. DOI: 10.3389/fphar.2015.00032
[5] VINAYAK SHENOY. Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.[J]. American journal of respiratory and critical care medicine, 2013, 187 6: 648-657. DOI: 10.1164/rccm.201205-0880oc |
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