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918132-15-7

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918132-15-7 Structure

918132-15-7 Structure
IdentificationBack Directory
[Name]

Boc-Aminooxy-PEG3-bromide
[CAS]

918132-15-7
[Synonyms]

Boc-Aminooxy-PEG3-bromide
t-Boc-Aminooxy-PEG3-bromide
tert-butyl N-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]carbamate
[Molecular Formula]

C13H26BrNO6
[MDL Number]

MFCD29764337
[MOL File]

918132-15-7.mol
[Molecular Weight]

372.25
Chemical PropertiesBack Directory
[density ]

1.265±0.06 g/cm3(Predicted)
[solubility ]

Soluble in DMSO, DCM, DMF
Hazard InformationBack Directory
[Description]

t-Boc-Aminooxy-PEG3-bromide is a crosslinker containing a t-Boc-aminooxy group and a bromide (Br). The bromide (Br) is a very good leaving group for nucleophilic substitution reactions.Thet-Boc- aminoxy can be deprotected under mild acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.
[Uses]

Boc-Aminooxy-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs; Alkyl/ether
[References]

[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651
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