| Identification | Back Directory | [Name]
Boc-Aminooxy-PEG3-bromide | [CAS]
918132-15-7 | [Synonyms]
Boc-Aminooxy-PEG3-bromide
t-Boc-Aminooxy-PEG3-bromide
tert-butyl N-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]carbamate | [Molecular Formula]
C13H26BrNO6 | [MDL Number]
MFCD29764337 | [MOL File]
918132-15-7.mol | [Molecular Weight]
372.25 |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG3-bromide is a crosslinker containing a t-Boc-aminooxy group and a bromide (Br). The bromide (Br) is a very good leaving group for nucleophilic substitution reactions.Thet-Boc- aminoxy can be deprotected under mild acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Boc-Aminooxy-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651 |
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