| Identification | Back Directory | [Name]
Boc-Aminooxy-PEG3-acid | [CAS]
1835759-82-4 | [Synonyms]
Boc-Aminooxy-PEG3-acid
t-Boc-Aminooxy-PEG3-acid | [Molecular Formula]
C14H27NO8 | [MDL Number]
MFCD29052175 | [MOL File]
1835759-82-4.mol | [Molecular Weight]
337.37 |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG3-acid is a PEG linker containing a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc-protected amine can be deprotected under mild acidic conditions. | [Uses]
Boc-Aminooxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|