| Identification | Back Directory | [Name]
Ac-Arg-Leu-Arg-AMC | [CAS]
929903-87-7 | [Synonyms]
Ac-RLR-AMC
Ac-Arg-Leu-Arg-AMC
Ac-Arg-Leu-Arg-AMC trifluoroacetate salt
N2-Acetyl-L-arginyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide
L-Argininamide,N2-acetyl-L-arginyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- | [Molecular Formula]
C30H46N10O6 | [MDL Number]
MFCD18782518 | [MOL File]
929903-87-7.mol | [Molecular Weight]
642.75 |
| Hazard Information | Back Directory | [Uses]
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes[1]. | [Biological Activity]
Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. It is cleaved exclusively at the amide R-AMC bond to release fluorescent product. Shows low Km and high specific activity. Excitation: 380nm. Emission: 460nm. This substrate is useful for inhibitor screening and kinetic analysis. | [storage]
+4°C | [References]
[1] Chang TL. Inhibitory effect of flavonoids on 26S proteasome activity. J Agric Food Chem. 2009 Oct 28;57(20):9706-15. DOI:10.1021/jf9017492 |
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