| Identification | More | [Name]
2-Ethoxybenzamide | [CAS]
938-73-8 | [Synonyms]
2-ETHOXYBENZAMIDE
2-ETHOXYBENZOYLAMIDE
ETHENZAMIDE
ETHOXYBENZAMIDE
O-ETHOXYBENZAMIDE
O-ETHYLSALICYLAMIDE
2-ethoxy-benzamid
2-Ethoxybenzenecarbonamide
Anovigam
Benzamide, 2-ethoxy-
Benzamide, o-ethoxy-
Etamide
Etenzamide
Ethbenzamide
Ethenzamid
Ethosalicyl
Ethylsalicylamide
Etocil
Etosalicil
Etosalicyl | [EINECS(EC#)]
213-346-4 | [Molecular Formula]
C9H11NO2 | [MDL Number]
MFCD00007977 | [Molecular Weight]
165.19 | [MOL File]
938-73-8.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE TO ALMOST WHITE GRANULAR CRYSTALLINE POWDER | [Melting point ]
132-134 °C (lit.) | [Boiling point ]
293.03°C (rough estimate) | [density ]
1.1603 (rough estimate) | [refractive index ]
1.5620 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Dichloromethane (Slightly) | [form ]
Granular Crystalline Powder | [pka]
15.62±0.50(Predicted) | [color ]
White to almost white | [Water Solubility ]
<0.1 g/100 mL at 16 ºC | [Merck ]
14,3731 | [InChI]
InChI=1S/C9H11NO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H2,10,11) | [InChIKey]
SBNKFTQSBPKMBZ-UHFFFAOYSA-N | [SMILES]
C(N)(=O)C1=CC=CC=C1OCC | [CAS DataBase Reference]
938-73-8(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethenzamide(938-73-8) | [EPA Substance Registry System]
938-73-8(EPA Substance) |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
2 | [RTECS ]
CU4381000 | [TSCA ]
Yes | [HS Code ]
29242995 | [Storage Class]
11 - Combustible Solids | [Toxicity]
LD50 orally in mice: 1160 mg/kg (Starmer) |
| Hazard Information | Back Directory | [General Description]
White or almost-white crystalline powder. Almost odorless. Tasteless. | [Reactivity Profile]
2-ETHOXYBENZAMIDE(938-73-8) is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). | [Air & Water Reactions]
Insoluble in water. | [Health Hazard]
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides. | [Fire Hazard]
Flash point data for this chemical are not available; however, 2-ETHOXYBENZAMIDE is probably combustible. | [Chemical Properties]
WHITE TO ALMOST WHITE GRANULAR CRYSTALLINE POWDER | [Originator]
Ethenzamide,Tongxiang Hengda | [Definition]
ChEBI: Ethenzamide is an organic molecular entity. | [Manufacturing Process]
500 g of salicylic amide are dissolved in 1.5 L of 10% alcohol by means of
146 g of sodium hydroxide. 560 g diethyl sulphate are added, the mixture is
frequently shaken during four hours and kept cold. 20 hours later the 2-
ethoxy-benzamide is precipitated in a gritty state and is removed by suction
and dried at 50°-100°C. The yield is 540 g or about 90%. MP: 130°C. | [Therapeutic Function]
Analgesic | [Clinical Use]
Ethenzamide is a nonsteroidal
anti-inflammatory drug used mainly in combination
with other ingredients for the treatment of
mild to moderate pain including musculoskeletal
and joint disorders. | [References]
[1] Tetrahedron Letters, 2017, vol. 58, # 43, p. 4090 - 4093
[2] Journal of Organic Chemistry, 2015, vol. 80, # 8, p. 4148 - 4151
[3] ChemCatChem, 2017, vol. 9, # 7, p. 1349 - 1353
[4] Patent: CN106588686, 2017, A. Location in patent: Paragraph 0023; 0025 |
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