| Identification | Back Directory | [Name]
Benzamide, N-[4-[[7-chloro-2,3,4,5-tetrahydro-5-(phosphonooxy)-1H-1-benzazepin-1-yl]carbonyl]-3-methylphenyl]-2-methyl-, sodium salt (1:2) | [CAS]
942619-79-6 | [Synonyms]
Benzamide, N-[4-[[7-chloro-2,3,4,5-tetrahydro-5-(phosphonooxy)-1H-1-benzazepin-1-yl]carbonyl]-3-methylphenyl]-2-methyl-, sodium salt (1:2) | [Molecular Formula]
C26H27ClN2NaO6P | [MOL File]
942619-79-6.mol | [Molecular Weight]
552.92 |
| Hazard Information | Back Directory | [Uses]
Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation[1][2]. | [References]
[1] Hiroyuki Fujiki, et al. In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan. J Pharmacol Sci. 2022 Nov;150(3):163-172. DOI:10.1016/j.jphs.2022.08.004
[2] Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95(4):324-36. DOI:10.1016/j.bcp.2015.03.015 |
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