| Identification | Back Directory | [Name]
Etilefrine hydrochloride | [CAS]
943-17-9 | [Synonyms]
Funasol
Epholin
Efotinon
Ehochlon
Kertasin
Phetanol
Pulsamin
Updormin
Circupon
Effontil
Effortil
Apocretin
Eti-Puren
Etilefrina
Effortilvet
Tonus-Forte
Ethyl adrianol
ETILEFRINE HCL
-1-hydroxyethyl)
3-(2-(Ethylamino)
Ethyladrianol HCl
phenol hydrochloride
LABOTEST-BB LT00244796
ETILEFRIN HYDROCHLORIDE
ETILEFRINE HYDROCHLORIDE
dl-Effortil hydrochloride
dl-Etilefrin hydrochloride
ETILEFRIN HYDROCHLORIDE 98+%
Ethylphenylephrin hydrochloride
dl-Ethylphenylephrine hydrochloride
(+-)-Ethylphenylephrine hydrochloride
dl-n-ethylnorphenylephrine hydrochloride
Etilefrine hydrochloride ###ETILEFRINE-D5
(+-)-N-Ethylnorphenylephrine hydrochloride
1-(3-Hydroxyphenyl)-2-ethylaminoethanol hydrochloride
3-[2-(ETHYLAMINO)-1-HYDROXYETHYL]PHENOL HYDROCHLORIDE
2-ETHYLAMINO-1-(3-HYDROXYPHENYL)ETHANOL HYDROCHLORIDE
dl-1-(3-Hydroxyphenyl)-2-ethylaminoethanol hydrochloride
2-Ethylamino-1-(3-hydroxyphenyl)-1-ethanol hydrochloride
α-[(Ethylamino)methyl]-m-hydroxybenzyl alcohol hydrochloride
alpha-((ethylamino)methyl)-m-hydroxy-benzylalcohohydrochloride
alpha-((ethylamino)methyl)-m-hydroxybenzylalcoholhydrochloride
alpha-((ethylamino)methyl)-3-hydroxy-benzenemethanohydrochloride
Benzenemethanol, α-[(ethylamino)methyl]-3-hydroxy-, hydrochloride
dl-1-(3-Hydroxyphenyl)-1-hydroxy-2-ethylaminoethane hydrochloride
Benzyl alcohol, α-[(ethylamino)methyl]-m-hydroxy-, hydrochloride (6CI, 8CI) | [EINECS(EC#)]
213-398-8 | [Molecular Formula]
C10H16ClNO2 | [MDL Number]
MFCD00060167 | [MOL File]
943-17-9.mol | [Molecular Weight]
217.69 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder or colourless crystals. | [Melting point ]
122 °C | [storage temp. ]
-20°C | [solubility ]
Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride | [form ]
neat | [color ]
White to off-white | [InChI]
InChI=1S/C10H15NO2.ClH/c1-2-11-7-10(13)8-4-3-5-9(12)6-8;/h3-6,10-13H,2,7H2,1H3;1H | [InChIKey]
KTNROWWHOBZQGK-UHFFFAOYSA-N | [SMILES]
Cl.OC1=CC=CC(=C1)C(O)CNCC | [Uses]
Adrenoceptor agonist. |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder or colourless crystals. | [Originator]
Circupon,Troponwerke,W. Germany | [Definition]
ChEBI: Etilefrine hydrochloride (TN) is a member of phenols. | [Manufacturing Process]
30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are
mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and
dissolved while warming. After heating for 1 hour under reflux, the acylation
is complete. After concentrating the reaction solution, the product is
precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2-
(N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water,
thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan-
1-one, dissolved in a 10-fold amount of water, are added dropwise at room
temperature and hydrogenation is carried out until 1 mol of hydrogen has
been taken up. After filtering off the catalyst, a further 3 parts of
palladium/charcoal are added and hydrogenation is carried out until a further
mol of hydrogen has been taken up. The catalyst is separated off and after
removal of the solvent the hydrogenation product is reprecipitated from
acetone/petroleum ether and from methanol/ether until it is pure according to
thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2-
ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C. | [Therapeutic Function]
Tranquilizer |
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