| Identification | Back Directory | [Name]
HSD-016 | [CAS]
946396-92-5 | [Synonyms]
HSD-016
Benzenemethanol, 3-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-α-methyl-α-(trifluoromethyl)-, (αR)- | [Molecular Formula]
C21H21F7N2O3S | [MOL File]
946396-92-5.mol | [Molecular Weight]
514.46 |
| Chemical Properties | Back Directory | [Melting point ]
102-104 °C | [Boiling point ]
563.9±60.0 °C(Predicted) | [density ]
1.421±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (194.38 mM; Need ultrasonic) | [form ]
Solid | [pka]
11.60±0.15(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HSD-016 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 values of 11, 1 and 8 nM against human, mouse and rat 11β-HSD1, respectively. HSD-016 can be used for type 2 diabetes research[1]. | [storage]
Store at -20°C | [References]
[1] Wan ZK, et al. Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016. J Org Chem. 2011 Sep 2;76(17):7048-55. DOI:10.1021/jo200958a |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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