| Identification | Back Directory | [Name]
Arisantetralone C | [CAS]
98619-25-1 | [Synonyms]
Schisandrone
Arisantetralone C
1(2H)-Naphthalenone, 4-(3,4-dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-2,3-dimethyl-, (2S,3S,4R)- | [Molecular Formula]
C21H24O5 | [MDL Number]
MFCD21333770 | [MOL File]
98619-25-1.mol | [Molecular Weight]
356.41 |
| Chemical Properties | Back Directory | [Melting point ]
180-181℃ | [Boiling point ]
508.2±50.0 °C(Predicted) | [density ]
1.159±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Cryst. | [pka]
9.38±0.70(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C21H24O5/c1-11-12(2)21(23)15-9-16(22)18(25-4)10-14(15)20(11)13-6-7-17(24-3)19(8-13)26-5/h6-12,20,22H,1-5H3/t11-,12+,20-/m1/s1 | [InChIKey]
DRKPZVVNEGETTG-XAAFQQQXSA-N | [SMILES]
C1(=O)C2=C(C=C(OC)C(O)=C2)[C@@H](C2=CC=C(OC)C(OC)=C2)[C@H](C)[C@@H]1C |
| Hazard Information | Back Directory | [Uses]
Schisandrone is a new 4-?aryltetralone lignan isolated from the dried fruits of Schisandra sphenanthera. Schisandrone improves learning and memory abilities of rats with Alzheimer-like disease. | [in vivo]
Schisandrone (40 mg/kg, s.c.) combined with antibiotic Ceftiofur exhibits a significant therapeutic effect on S. aureusinfection in mice[2].
| Animal Model: | S. aureus-infected mice[2] | | Dosage: | 40 mg/kg | | Administration: | Subcutaneous injection (s.c.) | | Result: | Combined with ceftiofur reduced The MIC of ceftiofur, from 32 μg/mL to 2 μg/mL.
Showed the survival rate of 30%.
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| [target]
NF-kB | NOS | Beta Amyloid |
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