Identification | Back Directory | [Name]
6-BroMoquinoline-2-carbaldehyde | [CAS]
98948-91-5 | [Synonyms]
6-BroMoquinoline-2-carbaldehyde 6-Bromo-2-quinolinecarboxaldehyde | [Molecular Formula]
C10H6BrNO | [MDL Number]
MFCD06824164 | [MOL File]
98948-91-5.mol | [Molecular Weight]
236.06 |
Chemical Properties | Back Directory | [Boiling point ]
370.7±22.0 °C(Predicted) | [density ]
1.632±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
2.85±0.43(Predicted) | [Appearance]
Light yellow to yellow Solid |
Hazard Information | Back Directory | [Uses]
6-Bromoquinoline-2-carboxaldehyde is a reagent used in the synthesis of histone deacetylase (HDAC) inhibitor; an anti-cancer agent. | [Synthesis]
At room temperature and under nitrogen protection, 6-bromo-2-methylquinoline (10 g, 45.0 mmol) was dissolved in 1,4-dioxane (100 mL), followed by the addition of selenium dioxide (6.00 g, 54.0 mmol). The reaction mixture was heated to 75°C and maintained at this temperature for 5 hours of reaction. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed with ethyl acetate. The filtrate was concentrated under reduced pressure and the resulting residue was ground with hexane to promote product precipitation. The solid product was collected by vacuum filtration and dried overnight under high vacuum to give the final 6-bromoquinoline-2-carbaldehyde (8.86 g, 37.5 mmol, 83% yield) as an off-white solid. The structure of the product was analyzed by 1H NMR (400 MHz, DMSO-d6) δ 10.11 (d, J=1.0 Hz, 1H), 8.56 (d, J=8.5 Hz, 1H), 8.43 (d, J=2.3 Hz, 1H), 8.14 (d, J=9.0 Hz, 1H), 8.05-8.02 (m, 1H), 8.02-8.00 ( m, 1H) and LCMS (ESI) m/z 235.9,237.9 [M+H]+ (calculated value C10H7BrNO 236.0) confirmed. | [References]
[1] Patent: WO2011/86469, 2011, A1. Location in patent: Page/Page column 25 [2] Angewandte Chemie - International Edition, 2018, vol. 57, # 35, p. 11374 - 11377 [3] Angew. Chem., 2018, vol. 130, p. 11544 - 11547,4 [4] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0063 [5] Journal of Fluorescence, 2018, vol. 28, # 3, p. 795 - 800 |
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Struchem Co., Ltd.
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0512-63009836 18994340901 |
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www.beidapharma.com |
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