1188296-52-7

中文名称无中文名称

英文名称 PF 4800567 hydrochloride

CAS 1188296-52-7

分子式 C17H18ClN5O2

分子量 359.81

MOL 文件 1188296-52-7.mol

更新日期 2026/01/27 15:55:09

1188296-52-7 结构式

基本信息物理化学性质安全数据应用领域图谱信息 PF 4800567价格(试剂级) 常见问题列表

基本信息

中文别名

化合物PF-4800567
PF-4800567游离态
3-[(3-氯苯氧基)甲基]-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺

英文别名

PF 4800567
PF 4800567
PF-4800567
PF 4800567 hydrochloride
3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine
3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-
3-[(3-Chlorophenoxy)Methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Hydrochloride

所属类别

生物：小分子化合物

物理化学性质

沸点592.9±50.0 °C(Predicted)

密度1.52±0.1 g/cm3(Predicted)

储存条件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml

酸度系数(pKa)4.01±0.30(Predicted)

形态结晶固体

颜色Light yellow to yellow

InChI1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21)

InChIKeyAUMDBEHGJRZSOO-UHFFFAOYSA-N

SMILESNC1=NC=NC2=C1C(COC3=CC=CC(Cl)=C3)=NN2C4CCOCC4

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P305+P351+P338

WGK GermanyWGK 2

存储类别11 - Combustible Solids

应用领域

用途1

PF 4800567 is a selective casein kinase 1蔚 inhibitor; displays 22-fold greater potency towards CK1蔚 than CK1δ (IC50 values are 32 and 711 nM for CK1蔚 and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.

图谱信息

PF 4800567(1188296-52-7)核磁图(¹HNMR)

PF 4800567价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/12/22	HY-12470	PF-4800567	1188296-52-7	1 mg	192元
2025/12/22	HY-12470	3-((3-氯苯氧基)甲基)-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺 PF-4800567	1188296-52-7	5mg	477元
2025/12/22	HY-12470	3-((3-氯苯氧基)甲基)-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺 PF-4800567	1188296-52-7	10mg	777元

常见问题列表

生物活性

PF 4800567是casein kinase 1 epsilon (IC50=32 nM) 的新型有效抑制剂，其选择性是casein kinase 1 delta(IC50=711 nM)的20倍以上。

靶点

Target	Value
casein kinase 1 epsilon (Cell-free assay)	32 nM
casein kinase 1 delta ()	711 nM

体外研究

PF-4800567 is a potent and selective inhibitor of casein kinase 1ϵ (CK1ϵ), with an IC ₅₀ of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC ₅₀ , 711 nM). PF-4800567 shows inhibitory activity against CK1ϵ and CK1δ in whole cells, with IC ₅₀ s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1ϵ-mediated PER3 nuclear localization mediated by CK1ϵ and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 has little effect on the circadian clock at 32 nM.

体内研究

PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice.