2316817-88-4
中文名称
CB-6644
英文名称
CB-6644
CAS
2316817-88-4
分子式
C29H34ClFN4O5
分子量
573.06
MOL 文件
2316817-88-4.mol
更新日期
2023/03/20 15:41:25
2316817-88-4 结构式
物理化学性质
密度1.34±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO:100.0(Max Conc. mg/mL);174.5(Max Conc. mM)
酸度系数(pKa)13.13±0.20(Predicted)
形态固体
颜色White to light yellow
CB-6644价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-114429 | CB-6644 CB-6644 | 2316817-88-4 | 1mg | 2800元 |
| 2025/05/22 | HY-114429 | CB-6644 CB-6644 | 2316817-88-4 | 5mg | 5600元 |
| 2025/05/22 | HY-114429 | CB-6644 CB-6644 | 2316817-88-4 | 10 mM * 1 mLin DMSO | 7060元 |
常见问题列表
生物活性
CB-6644 一种选择性的 RUVBL1/2 复合体抑制剂。抑制 RUVBL1/2 的 ATP 酶活性，IC50 为 15 nM。具有抗癌活性。体外研究
CB-6644 (20 µM) interacts with the RUVBL1/2 complex in Ramos cells.
CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (including HCT116, NCI-1975, and HT29 cells) with an EC
50
range of 41 to 785 nM.
Cell Viability Assay
| Cell Line: | 123 cell lines such as HCT116, NCI-1975, and HT29 cells |
| Concentration: | 0.001, 0.01, 0.1, 1, and 10 μM |
| Incubation Time: | 72 hours |
| Result: | Potently killed cells with an EC 50 range of 41 to 785 nM. |
体内研究
CB-6644 (150 mg/kg, oral administration, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models, 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models) has antitumor activity in xenograft tumor models with tumor growth inhibitions (TGIs) of 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.
| Animal Model: | SCID-beige mice bearing human tumor xenografts derived from either Burkitt’s lymphoma (Ramos) or multiple myeloma (RPMI8226) cell lines |
| Dosage: | 150 mg/kg |
| Administration: | Oral gavage once (qd) or twice (BID) daily, 10 days of treatment for Ramos, 30 days of treatment for RPMI8226 |
| Result: | There was no significant bodyweight loss in mice. TGI of 68 and 81% in Ramos and RPMI8226, respectively. |