578-74-5
578-74-5 结构式
基本信息
芹菜苷配基-7-O-葡糖苷
芹菜素-7-葡萄糖苷
芹菜甙元(芹菜素)-7-葡萄糖甙
芹菜甙元(芹菜素)-7-O-葡萄糖甙
芹菜素-7- O -葡萄糖苷
大波斯菊苷
芹菜甙元-7- 葡萄糖甙
芹菜甙元-7- O-葡萄糖甙
芹甙元-7-葡萄糖苷
COSMETIN
COSMOSIIN
APIGETRIN
Cosemetin
Cosmosioside
APIGENIN-7-GLUCOSIDE
Apigetrin, Cosmosiin
APIGENIN-7-O-GLUCOSIDE
Apigenin 7-β-D-glucoside
Apigenin 7-b-D-glucoside
Apigenin-7-O-β-D-glucoside
Apigenin 7-beta-D-glucoside
APIGENIN-7-O-GLUCOSIDE hplc
7-o-(beta-D-Glucosyl)apigenin
APIGENIN-7-O-GLUCOSIDE WITH HPLC
Apigenin-7-O-β-D-glucopyranoside
Apigenin, 7-beta-D-glucopyranoside
APIGENIN-7-GLUCOSIDE (COSMOSIIN)(P)
APIGENIN-7-O-GLUCOSIDE (COSMOSIIN)(P)
APIGENIN-7-O-GLUCOSIDE (COSMOSIIN)(SH)
Apigenin 7-glucoside SynonyMs:Apigetrin
7-O-BETA-D-GLUCOPYRANOSYLOXY-4',5-DIHYDROXYFLAVONE
4H-1-Benzopyran-4-one,7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)
4H-1-Benzopyran-4-one,7-(b-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-
7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 7- (.beta.-D-glucopyranosyloxy)-5-hydroxy-2-(4- hydroxyphenyl)-
4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)- (9ci)
物理化学性质
制备方法
![4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-7-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-](/CAS/20210305/GIF/119249-30-8.gif)
119249-30-8
578-74-5
在搅拌条件下，将化合物1（CAS: 119249-30-8，150 mg，0.25 mmol）溶于甲醇（20 mL）和30%氨水（5 mL）的混合溶液中。反应混合物在室温下持续搅拌12小时。反应完成后，通过减压蒸馏除去溶剂。所得残余物通过硅胶柱色谱法进行纯化，采用乙酸乙酯/甲醇（3:1，v/v）作为洗脱剂，得到目标产物5-羟基-2-(4-羟基苯基)-7-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-4H-苯并吡喃-4-酮，为黄色固体（78 mg，收率72%）。产物的熔点为234-236°C（文献值：238-239°C）。红外光谱（KBr压片，cm^-1）显示特征吸收峰：3440, 2918, 1615, 1563, 1452, 1346, 1273, 1245, 1146, 1103, 1072, 1024, 895。核磁共振氢谱（400 MHz, DMSO-d6）δ：12.97（s, 1H, OH-5），10.48（s, 1H, OH-4'），7.96（d, J = 8.8 Hz, 2H, H-2', H-6'），6.94（d, J = 8.8 Hz, 2H, H-3', H-5'），6.87（s, 1H, H-3），6.83（d, J = 1.6 Hz, 1H, H-8），6.45（d, J = 1.6 Hz, 1H, H-6），5.42（d, J = 8.0 Hz, 1H, H-1），5.15（s, 1H, OH-2），5.08（s, 1H, OH-3），5.06（s, 1H, OH-4），4.63（s, 1H, OH-6），3.72-3.70（m, 1H, H-2），3.49-3.18（m, 5H, H-3,4,5,6）。核磁共振碳谱（100 MHz, DMSO-d6）δ：60.6, 69.6, 73.1, 76.5, 77.2, 94.8, 99.6, 99.9, 103.1, 105.4, 116.0, 121.1, 128.6, 156.9, 161.1, 161.4, 163.0, 164.3, 180.1。高分辨质谱（HRMS）计算值[M + Na]+ C21H20O10Na为455.3665，实测值为455.3649。
参考文献：
[1] Tetrahedron, 2004, vol. 60, # 9, p. 2025 - 2034
[2] Carbohydrate Research, 2012, vol. 357, p. 41 - 46
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/09/19 | S9125 | 芹甙元-7-葡萄糖苷 Apigetrin | 578-74-5 | 1mg | 1040.37元 |
| 2025/05/22 | HY-N0578 | 芹甙元-7-葡萄糖苷 Apigenin 7-glucoside | 578-74-5 | 1 mg | 409元 |
| 2025/05/22 | HY-N0578 | 芹甙元-7-葡萄糖苷 Apigenin 7-glucoside | 578-74-5 | 10 mM * 1 mLin DMSO | 904元 |
常见问题列表
Apigenin 7-glucoside exhibits significant anti-proliferative activity against B16F10 melanoma cells after 24 and 48 h of incubation. Apigenin-7-glucoside provoks an increase of subG0/G1, S and G2/M phase cell proportion with a significant decrease of cell proportion in G0/G1 phases. Apigenin-7-glucoside enhances melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells.
Apigenin 7-glucoside specifically induces the differentiation of CD34
+
cells towards the erythroid lineage and inhibited the myeloid differentiation. Apigenin 7-glucoside has strong antioxidant activity against reactive oxygen species (ROS) in vitro in a concentration-dependent manner.