88206-46-6
中文名称
羌活醇
英文名称
Notopterol
CAS
88206-46-6
分子式
C21H22O5
分子量
354.4
MOL 文件
88206-46-6.mol
更新日期
2025/06/30 09:01:29
88206-46-6 结构式
基本信息
中文别名
羌活醇(标准品)羌活醇, 来源于羌活
羌活醇(分析标准品)
羌活醇NOTOPTEROL
NOTOPTEROL 羌活醇
英文别名
NotoperolNotopterol, 98%, from Notopterygium incisum C. T. Ting ex H. T. Chang
(E)-4-((5-Hydroxy-3,7-dimethylocta-2,6-dien-1-yl)oxy)-7H-furo[3,2-g]chromen-7-one
(E)-4-[(5-Hydroxy-3,7-dimethyl-2,6-octadien-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one
4-[[(2E)-5-Hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy]-7H-furo[3,2-g][1]benzopyran-7-one
7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-5-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy]-
7H-Furo[3,2-g][1]benzopyran-7-one,4-[[(2E)-5-hydroxy-3,7-diMethyl-2,6-octadienyl]oxy]-(9CI)
所属类别
生物化工：提取物物理化学性质
外观性状白色针状结晶，易溶于甲醇，来源于羌活根茎。
沸点546.7±50.0 °C(Predicted)
密度1.216
储存条件Sealed in dry,2-8°C
溶解度Soluble in acetonitrile, chloroform and methanol;
酸度系数(pKa)14.63±0.20(Predicted)
形态粉末
颜色白色
水溶解性不溶于水
常见问题列表
生物活性
Notopterol 是从 N. incisum 提取的香豆素。Notopterol 诱导细胞凋亡，具有解热，镇痛和抗炎作用。Notopterol 有用于急性髓细胞性白血病 (AML) 的潜力。体外研究
notopterol (5, 10, 20, 40, 60 μM; for 48 hours) promotes cell apoptosis in a dose-dependent manner.
notopterol (10, 20, 40, 60 and 80 μM; 24-120 hours) inhibits the proliferation of HL-60 cells in a concentration-dependent manner.
Notopterol (5, 10, 20 and 40 μM; for 48 hours) induces G0/G1 phase arrest associated with cell-cycle proteins in HL-60 cells.
Notopterol (5, 10, 20 and 40 μM; for 48 hours) increases the expression of Bax and decreased the expression of Bcl-2 and Mcl-1 in HL-60 cells after 48-hr treatment. Moreover, Notopterol also promotes the cleavage of caspase 9, caspase 3 and PARP.