考迈斯托醇
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- CAS号:
- 479-13-0
- 英文名:
- COUMESTROL
- 英文别名:
- Coumesterol;3,9-Dihydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one;Nsc22842;Cumostrol;Cumoestrol;COUMESTROL;COUMOESTROL;cumoesterol;COUMESTROL(P);Coumestrol,99%
- 中文名:
- 考迈斯托醇
- 中文别名:
- 香豆雌酚;拟雌内酯;考迈斯托醇;香豆雌酚(拟雌内酯;拟雌内酯, >98%;香豆雌酚；拟雌内酯；考迈斯托醇;Coumestrol[27885];【进口原装】香豆雌酚479-13-0;拟雌内酯,10 MM DMSO 溶液;【进口原装】香豆雌酚479-13-0
- CBNumber:
- CB2339816
- 分子式:
- C15H8O5
- 分子量:
- 268.22
- MOL File:
- 479-13-0.mol
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考迈斯托醇化学性质
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熔点:
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≥350 °C(lit.)
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沸点:
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331.39°C (rough estimate)
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密度:
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1.2586 (rough estimate)
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折射率:
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1.7680 (estimate)
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储存条件:
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Refrigerator
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溶解度:
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DMSO: soluble
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酸度系数(pKa):
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8.25±0.20(Predicted)
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形态:
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Light beige solid.
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颜色:
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Pale Yellow to Dark Brown
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BRN:
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266702
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InChI:
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InChI=1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H
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InChIKey:
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ZZIALNLLNHEQPJ-UHFFFAOYSA-N
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SMILES:
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C1(=O)OC2=CC(O)=CC=C2C2OC3=CC(O)=CC=C3C1=2
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LogP:
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2.940 (est)
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CAS 数据库:
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479-13-0(CAS DataBase Reference)
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EPA化学物质信息:
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Coumestrol (479-13-0)
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考迈斯托醇性质、用途与生产工艺
Coumestrol是大豆产品中存在的植物雌激素。可用于癌症，神经障碍和自身免疫疾病的研究。抑制ES2细胞增殖的IC50值为50 μM。
Coumestrol exerts chemotherapeutic effects via PI3K and ERK1/2 MAPK pathways. Coumestrol inhibits viability and invasion, and induces apoptosis of ES2 (clear cell-/serous carcinoma origin) cells. In addition, immunoreactive PCNA and ERBB2, markers of proliferation of ovarian carcinoma, are attenuated in their expression in coumestrol-induced death of ES2 cells. Phosphorylation of AKT, p70S6K, ERK1/2, JNK1/2 and p90RSK is inactivated by coumestrol treatment in a dose- and time-dependent manner. Coumestrol inhibits proliferation and induces apoptosis in MCF-7 cells, which is prevented by copper chelator neocuproine and ROS scavengers. Coumestrol treatment induces ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation.
考迈斯托醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2026/06/05 | HY-N2335R | 考迈斯托醇
Coumestrol (Standard) | 479-13-0 | 1 mg | 1250元 |
| 2026/06/05 | HY-N2335R | 考迈斯托醇
Coumestrol (Standard) | 479-13-0 | 5 mg | 2500元 |
考迈斯托醇
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考迈斯托醇国内生产厂家
479-13-0, 考迈斯托醇 相关搜索:
- Iso-Flavones
- Coumarins
- Steroids
- Steroids & Hormones - 13C & 2H
- 标准品
- 香豆素
- 抑制剂
- 试剂
- 对照品
- 木脂素
- 植物提取物
- 细胞生物学试剂
- 对照品
- C15H8O5
- C15H9O5
- 【进口原装】香豆雌酚479-13-0
- 香豆雌酚；拟雌内酯；考迈斯托醇
- 【进口原装】香豆雌酚479-13-0
- Coumestrol[27885]
- 拟雌内酯,10 MM DMSO 溶液
- 3,9-二羟基-6H-苯并呋喃并[3,2-C]苯并吡喃-6-酮
- 香豆雌酚(拟雌内酯
- 考迈斯托醇
- ES2细胞增殖抑制剂(COUMESTROL)
- 香豆雌酚
- 拟雌内酯
- 拟雌内酯, >98%
- 479-13-0
- Coumesterol
- 3,9-Dihydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one
- 3,9-Dihydroxy-6H-benzofuro[3,2-c]chromen-6-one , Coumestrol
- Coumestrol[27885]
- Coumestrol, 10 mM in DMSO
- 7’, 6-Dihydroxycoumarino(3’, 4’, 3, 2)Coumarone
- 5,14-dihydroxy-8,17-dioxatetracyclo[8.7.0.02,?.011,1?]heptadeca-1(10),2(7),3,5,11(16),12,14-heptaen-9-one
- Coumestrol (Synthetic)
- 3,9-Dihydroxy-6H-benzofuro[3,2-c]chromen-6-one
- Coumestrol ( synthitic)
- 2-c][1]benzopyran-6-one,3,9-dihydroxy-6h-benzofuro[
- 2-c)(1)benzopyran-6-one,3,9-dihydroxy-6h-benzofuro(
- 2-(2,4-dihydroxyphenyl)-6-hydroxy-3-benzofurancarboxylicacidelta-lacton
- 3,9-DIHYDROXY-6H-BENZOFURO[3,2-C]-[1]BENZOPYRAN-6-ONE
- COUMESTROL BIOREAGENT, SUITABLE FOR
- COUMESTROL
- 2-(2 4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID D-LACTONE
- 2-(2,4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID DELTA-LACTONE
- [2-(2,4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURAN-CARBOXYLIC ACID ALPHA-LACTONE]
- 7(1), 6-DIHYDROXYCOUMARINO(3(1), 4(1), 3,2)COUMARONE
- 7,12-DIHYDROXYCOUMESTANE
- 7,12-DIHYDROXYCOUMESTAN
- 2-(2,4-Dihydroxyphenyl)-6-hydroxy-3-benzofurancarboxylic Acid δ-Lactone
- Nsc22842
- Cumostrol
- Cumoestrol
- 6H-Benzofuro[3,2-C][1]benzopyran-6-one, 3,9-dihydroxy-
- 3-Benzofurancarboxylic acid, 2-(2,4-dihydroxyphenyl)-6-hydroxy-, .delta.-lactone
- Coumestrol,99%
- 2-(2 4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID D-LACTONE 98%